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使用化学和绿色方法对纳米复合材料进行比较合成与表征,包括对其[此处原文缺失具体物质]和生物学特性的比较研究。

Comparative synthesis and characterization of nanocomposites using chemical and green approaches including a comparison study on and biological properties.

作者信息

G Sabeena, S Vainath Praveen, E Pushpalakshmi, G Annadurai

机构信息

Sri Paramakalyani Centre of Excellence in Environmental Sciences, Manonmaniam Sundaranar University Alwarkurichi - 627412 India

出版信息

Nanoscale Adv. 2022 Dec 13;5(3):767-785. doi: 10.1039/d2na00677d. eCollection 2023 Jan 31.

DOI:10.1039/d2na00677d
PMID:36756509
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9890937/
Abstract

In this study, the anti-diabetic, anti-inflammatory, anti-cytotoxic, and antibacterial effects of various substances were studied . Malachite green's photocatalytic effects were used to determine the optimised sample while it was exposed to visible light. The intended nanocomposites were created without any contaminants, according to XRD data. The overall characterisation results of the green synthesis of CS/SiO/TiO/CeO/FeO nanocomposites (CSTCF(G)) were superior to those of the chemical synthesis of CS/SiO/TiO/CeO/FeO nanocomposites (CSTCF(C)). At the five doses examined, the green synthesis of CS/SiO/TiO/CeO/FeO nanocomposites (CSTCF(G)) and chemical synthesis of CS/SiO/TiO/CeO/FeO nanocomposites (CSTCF(C)) resulted in higher α-glucosidase inhibition percentages in the antidiabetic assay. HaCaT cells and MCF-7 cells were less harmful when treated with chemically synthesized CS/SiO/TiO/CeO/FeO nanocomposites (CSTCF(C)), and green synthesized CS/SiO/TiO/CeO/FeO nanocomposites (CSTCF(G)). From the results of the cytotoxicity tests against MCF-7 cells and HaCaT cells using the nanocomposites, the IC values of , green synthesized CS/SiO/TiO/CeO/FeO nanocomposites (CSTCF(G)), and chemically synthesized CS/SiO/TiO/CeO/FeO nanocomposites (CSTCF(C)) were calculated. This research work shows that the green synthesized CS/SiO/TiO/CeO/FeO nanocomposites (CSTCF(G)) have strong anti-inflammatory, antibacterial and anti-diabetic properties, as well as considerable suppression of high activation in zebrafish embryo toxicity. The novelty of this study focused on the revelation that green synthesized nanocomposites are more affordable, environmentally friendly and biocompatible than chemically synthesized ones.

摘要

在本研究中,对各种物质的抗糖尿病、抗炎、抗细胞毒性和抗菌作用进行了研究。孔雀石绿的光催化作用被用于确定在可见光照射下的优化样品。根据X射线衍射数据,所制备的纳米复合材料没有任何污染物。CS/SiO/TiO/CeO/FeO纳米复合材料(CSTCF(G))绿色合成的总体表征结果优于CS/SiO/TiO/CeO/FeO纳米复合材料(CSTCF(C))化学合成的结果。在所检测的五个剂量下,CS/SiO/TiO/CeO/FeO纳米复合材料(CSTCF(G))的绿色合成和CS/SiO/TiO/CeO/FeO纳米复合材料(CSTCF(C))的化学合成在抗糖尿病试验中导致更高的α-葡萄糖苷酶抑制率。用化学合成的CS/SiO/TiO/CeO/FeO纳米复合材料(CSTCF(C))和绿色合成的CS/SiO/TiO/CeO/FeO纳米复合材料(CSTCF(G))处理时,对HaCaT细胞和MCF-7细胞的危害较小。根据使用纳米复合材料对MCF-7细胞和HaCaT细胞进行细胞毒性测试的结果,计算了绿色合成的CS/SiO/TiO/CeO/FeO纳米复合材料(CSTCF(G))和化学合成的CS/SiO/TiO/CeO/FeO纳米复合材料(CSTCF(C))的半数抑制浓度值。这项研究工作表明,绿色合成的CS/SiO/TiO/CeO/FeO纳米复合材料(CSTCF(G))具有很强的抗炎、抗菌和抗糖尿病特性,以及对斑马鱼胚胎毒性中高活性的显著抑制作用。本研究的新颖之处在于揭示了绿色合成的纳米复合材料比化学合成的纳米复合材料更经济实惠、环保且具有生物相容性。

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