Buchmann U, Kalbhen D A
Z Rheumatol. 1985 May-Jun;44(3):100-7.
In good correlation to earlier results in hens we found that after intraarticular injections of iodo-acetate into the knee joint of rats, degenerative alterations of the articular cartilage and subchondral bone tissue develop within 2-4 months. The radiological, histological and macroscopical appearance of these degenerative processes in rats is quite similar to those in human osteoarthrosis (OA). Drug treatment of these rats with twice weekly subcutaneous doses of 1.0 mg, 2.0 mg or 5.0 mg glycosaminoglycan polysulphate = GAGPS (Arteparon) per kg body weight caused a pronounced and in many cases highly significant reduction of the intensity of experimental osteoarthrosis within the first 9 weeks. Due to the very severe acceleration of OA (induced by the high dose of 1.0 mg iodo-acetate) GAGPS could not influence the further progression of cartilage degeneration and destruction during the period of 12-15 weeks. The present results on rats confirm our preceding studies with biochemically induced OA in hens and demonstrate the identical reactions of both animal species to induction and therapy of degenerative joint disease.
与我们之前在母鸡身上得到的结果高度相关的是，我们发现，给大鼠膝关节内注射碘乙酸后，关节软骨和软骨下骨组织会在2至4个月内出现退行性改变。大鼠这些退行性病变过程的放射学、组织学和大体外观与人类骨关节炎（OA）的情况非常相似。用每千克体重每周两次皮下注射1.0毫克、2.0毫克或5.0毫克硫酸化糖胺聚糖（GAGPS，商品名：安特罗）对这些大鼠进行药物治疗，在最初9周内使实验性骨关节炎的严重程度显著降低，且在许多情况下具有高度统计学意义。由于OA的加速发展非常严重（由高剂量1.0毫克碘乙酸诱导），GAGPS在12至15周期间无法影响软骨退变和破坏的进一步发展。目前在大鼠身上得到的结果证实了我们之前对母鸡进行的生化诱导性OA的研究，并证明了这两种动物对退行性关节疾病的诱导和治疗具有相同的反应。
