School of Medicine, University of Leeds, Leeds, UK.
Department of Neurosurgery, The General Infirmary at Leeds, Great George Street, Leeds, LS1 3EX, UK.
J Neurooncol. 2023 Feb;161(3):451-467. doi: 10.1007/s11060-023-04246-1. Epub 2023 Feb 9.
Brain tumors cause morbidity and mortality in part through peritumoral brain edema. The current main treatment for peritumoral brain edema are corticosteroids. Due to the increased recognition of their side-effect profile, there is growing interest in finding alternatives to steroids but there is little formal study of animal models of peritumoral brain edema. This study aims to summarize the available literature.
A systematic search was undertaken of 5 literature databases (Medline, Embase, CINAHL, PubMed and the Cochrane Library). The generic strategy was to search for various terms associated with "brain tumors", "brain edema" and "animal models".
We identified 603 reports, of which 112 were identified as relevant for full text analysis that studied 114 peritumoral brain edema animal models. We found significant heterogeneity in the species and strain of tumor-bearing animals, tumor implantation method and edema assessment. Most models did not produce appreciable brain edema and did not test for observable manifestations thereof.
No animal model currently exists that enable the investigation of novel candidates for the treatment of peritumoral brain edema. With current interest in alternative treatments for peritumoral brain edema, there is an unmet need for clinically relevant animal models.
脑肿瘤导致发病率和死亡率的部分原因是肿瘤周围脑水肿。目前治疗肿瘤周围脑水肿的主要方法是皮质类固醇。由于皮质类固醇副作用的认识不断增加，人们越来越关注寻找替代类固醇的方法，但对于肿瘤周围脑水肿的动物模型的研究很少。本研究旨在总结现有文献。
对 5 个文献数据库（Medline、Embase、CINAHL、PubMed 和 Cochrane Library）进行了系统搜索。一般策略是搜索与“脑肿瘤”、“脑水肿”和“动物模型”相关的各种术语。
我们共发现了 603 份报告，其中 112 份被确定为全文分析的相关报告，这些报告研究了 114 种肿瘤周围脑水肿动物模型。我们发现，携带肿瘤动物的物种和品系、肿瘤植入方法和水肿评估存在显著的异质性。大多数模型没有产生明显的脑水肿，也没有检测到可观察到的脑水肿表现。
目前还没有一种动物模型能够对治疗肿瘤周围脑水肿的新候选药物进行研究。由于目前对肿瘤周围脑水肿的替代治疗方法很感兴趣，因此迫切需要临床相关的动物模型。
