Cimino M C, Rowley J D, Kinnealey A, Variakojis D, Golomb H M
Cancer Res. 1979 Jan;39(1):227-38.
Karyotypes were analyzed by routine Giemsa and quinacrine fluorescence for 16 patients with acute lymphocytic leukemia [ten adults (18 to 51 years) and six children (3 to 15 years)]. Four patients had received previous therapy, but all 16 had active disease when they were first studied. Eight patients (five untreated) had a normal karyotype initially; however, three of these developed a chromosomal abnormality during relapse. Eight patients had a chromosomal abnormality in their initial samples. Each of the 11 patients had different abnormalities. All chromosomes except Nos. 3, 5, 15, 16, and Y were involved in the various aneuploidies. One patient had a Ph1 chromosome due to a translocation with No. 21: t(21;22)(q22;q11). A patient with B-cell acute lymphocytic leukemia had a 14q+ marker in addition to other abnormalities. The median survival of patients with initially normal karyotypes may be longer than that of patients whose karyotypes are abnormal initially.
对16例急性淋巴细胞白血病患者（10例成人，年龄18至51岁；6例儿童，年龄3至15岁）进行了常规吉姆萨染色和喹吖因荧光核型分析。4例患者曾接受过先前治疗，但在首次研究时所有16例患者均患有活动性疾病。8例患者（5例未治疗）最初核型正常；然而，其中3例在复发期间出现了染色体异常。8例患者在初始样本中存在染色体异常。11例患者中的每例都有不同的异常情况。除3号、5号、15号、16号和Y染色体外，所有染色体都参与了各种非整倍体情况。1例患者因与21号染色体发生易位：t(21;22)(q22;q11)而具有Ph1染色体。1例B细胞急性淋巴细胞白血病患者除其他异常外，还有一个14q+标记。初始核型正常的患者的中位生存期可能比初始核型异常的患者更长。
