Gentsch C, Lichtsteiner M, Feer H
Psychiatric University Clinic Basle, Biochemical Laboratory, Switzerland.
Behav Brain Res. 1987 Aug;25(2):101-7. doi: 10.1016/0166-4328(87)90003-9.
An interstrain comparison was conducted between male spontaneously hypertensive rats and Wistar-Kyoto rats, in both the open field and the elevated plus-maze. Wistar-Kyoto rats, as compared to the hypertensive animals, showed, beside an attenuated locomotor activity in both test situations, a higher reaction to aversive environments (less entries into the central area of the open field and less visits to the open arms of the elevated plus-maze). Chlordiazepoxide, as potent anxiolytic, increased (1) general activity, (2) the frequency of entries into the open area of the open field, and (3) the number of visits to the open arms of the elevated plus-maze in both rat strains.
在旷场试验和高架十字迷宫试验中，对雄性自发性高血压大鼠和Wistar-Kyoto大鼠进行了品系间比较。与高血压动物相比，Wistar-Kyoto大鼠在两种试验情境下均表现出运动活性减弱，对厌恶环境的反应更强（进入旷场中央区域的次数更少，访问高架十字迷宫开放臂的次数更少）。强效抗焦虑药氯氮卓增加了两种品系大鼠的（1）总体活动、（2）进入旷场开放区域的频率以及（3）访问高架十字迷宫开放臂的次数。
