Hughey D J, Koppenaal R J
New York University.
Behav Neurosci. 1987 Oct;101(5):634-43. doi: 10.1037//0735-7044.101.5.634.
In these experiments, we used a new procedure to study cognitive mapping in normal rats and those with hippocampal lesions by observing their behavioral responses to a rearrangement of intramaze cues. Controls learned cognitive maps, and their goal-directed behavior was disrupted by a change in the cue sequence. A comparison of pre- and postoperatively trained rats with hippocampal lesions (HPLs) showed that hippocampal damage prevented the acquisition, but not retrieval, of cognitive maps. HPL subjects learned a discrimination between mazes as quickly as controls did, but learning did not facilitate the acquisition of maps. The rats with lesions were moderately impaired in a discrimination reversal, but their behavior suggested that they could sometimes interrupt and correct their errors. In summary, controls and HPLs were equally able to run the mazes, but additional testing revealed a dissociation between the learning and performance of the two groups. These data add to our understanding of how normal rats learn about their environment and how HPL damage affects this type of learning.
在这些实验中，我们采用了一种新方法，通过观察正常大鼠和海马损伤大鼠对迷宫内部线索重新排列的行为反应，来研究认知地图。对照组学会了认知地图，线索序列的改变打乱了它们的目标导向行为。对术前和术后训练的海马损伤大鼠（HPL）进行比较，结果显示海马损伤会阻碍认知地图的获取，但不会影响其提取。HPL实验对象学习迷宫辨别和对照组一样快，但这种学习并未促进地图的获取。损伤大鼠在辨别反转任务中受到中度损害，但其行为表明它们有时能够中断并纠正错误。总之，对照组和HPL大鼠在跑完迷宫方面能力相当，但进一步测试发现两组在学习和表现上存在分离。这些数据增进了我们对正常大鼠如何了解其环境以及HPL损伤如何影响这类学习的理解。
