寡糖的化学合成及其在新药研究中的应用。
Chemical synthesis of oligosaccharides and their application in new drug research.
机构信息
Inner Mongolia University Research Center for Glycochemistry of Characteristic Medicinal Resources, School of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China.
Inner Mongolia University Research Center for Glycochemistry of Characteristic Medicinal Resources, School of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China; Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 Place Jussieu, 75005, Paris, France; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, China.
出版信息
Eur J Med Chem. 2023 Mar 5;249:115164. doi: 10.1016/j.ejmech.2023.115164. Epub 2023 Feb 1.
Oligosaccharides are the ubiquitous molecules of life. In order to translate human bioglycosylation into clinical applications, homogeneous samples of oligosaccharides and glycoconjugates can be obtained by chemical, enzymatic or other biological methods for systematic studies. However, the structural complexity and diversity of glycans and their conjugates present a major challenge for the synthesis of such molecules. This review summarizes the chemical synthesis methods of oligosaccharides, the application of oligosaccharides in the field of medicinal chemistry according to their related biological activities, and shows the great prospect of oligosaccharides in the field of pharmaceutical chemistry.
寡糖是普遍存在的生命分子。为了将人类生物糖基化转化为临床应用，通过化学、酶或其他生物学方法可以获得寡糖和糖缀合物的均相样品，以便进行系统研究。然而，聚糖及其缀合物的结构复杂性和多样性对这些分子的合成提出了重大挑战。本文综述了寡糖的化学合成方法，根据其相关生物活性，介绍了寡糖在药物化学领域的应用，并展示了寡糖在药物化学领域的广阔前景。
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