寡糖合成与翻译创新。
Oligosaccharide Synthesis and Translational Innovation.
机构信息
Department of Chemistry , The Scripps Research Institute , 10550 N. Torrey Pines Road , La Jolla , California 92037 , United States.
Genomics Research Center, Academia Sinica , Taipei 115 , Taiwan.
出版信息
J Am Chem Soc. 2019 Mar 6;141(9):3735-3754. doi: 10.1021/jacs.8b11005. Epub 2019 Feb 18.
Abstract
The translation of biological glycosylation in humans to the clinical applications involves systematic studies using homogeneous samples of oligosaccharides and glycoconjugates, which could be accessed by chemical, enzymatic or other biological methods. However, the structural complexity and wide-range variations of glycans and their conjugates represent a major challenge in the synthesis of this class of biomolecules. To help navigate within many methods of oligosaccharide synthesis, this Perspective offers a critical assessment of the most promising synthetic strategies with an eye on the therapeutically relevant targets.
摘要
将人类的生物糖基化翻译为临床应用需要使用化学、酶或其他生物学方法获得均一的寡糖和糖缀合物样品，进行系统研究。然而，聚糖及其缀合物的结构复杂性和广泛变化给这类生物分子的合成带来了重大挑战。为了在许多寡糖合成方法中提供帮助，本文从治疗相关靶点的角度，对最有前途的合成策略进行了批判性评估。
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