Lister R G, Karanian J W
Laboratory of Clinical Studies, NIAAA, Bethesda, MD 20892.
Alcohol. 1987 Sep-Oct;4(5):409-11. doi: 10.1016/0741-8329(87)90076-0.
RO 15-4513, an imidazodiazepine that has been reported to reverse some of the behavioral effects of ethanol, was given to DBA/2 mice. Although no animals treated with a 6 mg/kg dose of this drug had seizures, 20% of animals given 20 mg/kg of this drug had tonic seizures. Ethanol withdrawal was induced in DBA/2 mice treated with 4-methyl pyrazole using an inhalation paradigm. Mice were more likely to have a seizure during ethanol withdrawal if treated with RO 15-4513 (6 mg/kg) than if they received the vehicle. These data suggest administering RO 15-4513 as an alcohol antagonist to alcoholic subjects may increase the incidence of seizures.
RO 15 - 4513是一种咪唑并二氮杂䓬，据报道它能逆转乙醇的一些行为效应，将其给予DBA/2小鼠。尽管给予6毫克/千克剂量这种药物的动物没有出现癫痫发作，但给予20毫克/千克这种药物的动物中有20%出现了强直性癫痫发作。使用吸入模式在接受4 - 甲基吡唑治疗的DBA/2小鼠中诱导乙醇戒断。与接受赋形剂的小鼠相比，用RO 15 - 4513（6毫克/千克）治疗的小鼠在乙醇戒断期间更有可能出现癫痫发作。这些数据表明，将RO 15 - 4513作为酒精拮抗剂给予酗酒者可能会增加癫痫发作的发生率。
