Department of Immunology, Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China.
Jiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research, Yangzhou University, Yangzhou, China.
Int J Cancer. 2023 Sep 1;153(5):904-917. doi: 10.1002/ijc.34471. Epub 2023 Feb 23.
Tumor microenvironment, the soil where tumor thrives, plays a critical role in the development and progression of colorectal cancer (CRC). Various cell signaling molecules in the environment promote tumor angiogenesis, immune tolerance and facilitate immune escape. Exosomes, as messengers between tumor and host cells, are considered key mediators involved in the tumor-accelerating environment. However, the exosome-mediated communication networks in the CRC microenvironment are still largely unclear. In this review, we summarized the relationship between TME and CRC based on recent literature. Then, we revealed the unique impacts and signal molecules of exosomes on account of their regulatory role in the flora, hypoxia, inflammatory and immunological microenvironment of CRC. Finally, we summarized the therapeutically effective of exosomes in CRC microenvironment and discussed their current status and prospects, aiming to provide new molecular targets and a theoretical basis for the CRC treatment.
肿瘤微环境是肿瘤赖以生存的“土壤”，在结直肠癌（CRC）的发生发展中起着关键作用。环境中的各种细胞信号分子促进肿瘤血管生成、免疫耐受，并有助于免疫逃逸。外泌体作为肿瘤细胞和宿主细胞之间的信使，被认为是参与肿瘤促进环境的关键介质。然而，CRC 微环境中外泌体介导的通讯网络在很大程度上仍不清楚。在这篇综述中，我们根据最近的文献总结了 TME 与 CRC 之间的关系。然后，我们揭示了外泌体对 CRC 微环境中菌群、缺氧、炎症和免疫的独特影响和信号分子，因为它们在这些方面发挥着调节作用。最后，我们总结了外泌体在 CRC 微环境中的治疗效果，并讨论了它们的现状和前景，旨在为 CRC 的治疗提供新的分子靶点和理论基础。
