Wren C, Peart I, Bain H, Hunter S
Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne.
Br Heart J. 1987 Oct;58(4):369-73. doi: 10.1136/hrt.58.4.369.
Fifteen patients aged 1-19 years (mean 10.9) with previously unoperated aortic coarctation underwent percutaneous balloon angioplasty between January 1985 and February 1986. Nine (60%) were hypertensive at presentation. Under general anaesthetic the systolic coarctation gradient was 24-50 mm Hg (mean 29) and the coarctation diameter was 4-9 mm (mean 5.5). Meditech balloon catheters 8-18 mm in diameter were inflated 1-4 times at 410-760 kPa. After dilatation the systolic coarctation gradient decreased to 0-20 mm Hg (mean 6) and the coarctation diameter increased to 7-20 mm (mean 12). One patient developed a fusiform aneurysm of the aorta at the coarctation site immediately after the procedure. At reinvestigation 6-16 months (mean 12.5) after dilatation 14 of the 15 patients were normotensive. In 13 patients the residual coarctation gradient was 0-10 mm Hg (mean 3). Two patients had recoarctation with residual gradients of 20 and 24 mm Hg and underwent successful repeat dilatation. One patient had developed a small discrete aneurysm at the coarctation site. Balloon angioplasty is thus a safe and effective method of relieving unoperated aortic coarctation. The frequency of aortic aneurysm and recoarctation is small and probably related to balloon size. This early experience is encouraging, but long term results and further experience are required before this approach is used to treat coarctation generally.
1985年1月至1986年2月期间,15例年龄在1 - 19岁(平均10.9岁)、此前未接受过手术治疗的主动脉缩窄患者接受了经皮球囊血管成形术。9例(60%)患者就诊时患有高血压。在全身麻醉下,缩窄部位的收缩期压差为24 - 50 mmHg(平均29 mmHg),缩窄处直径为4 - 9 mm(平均5.5 mm)。使用直径8 - 18 mm的Meditech球囊导管,在410 - 760 kPa的压力下充气1 - 4次。扩张后,缩窄部位的收缩期压差降至0 - 20 mmHg(平均6 mmHg),缩窄处直径增至7 - 20 mm(平均12 mm)。1例患者在术后即刻出现了缩窄部位的梭形主动脉瘤。在扩张后6 - 16个月(平均12.5个月)进行复查时,15例患者中有14例血压正常。13例患者的残余缩窄压差为0 - 10 mmHg(平均3 mmHg)。2例患者出现再缩窄,残余压差分别为20 mmHg和24 mmHg,并成功接受了再次扩张。1例患者在缩窄部位出现了一个小的孤立性动脉瘤。因此,球囊血管成形术是一种安全有效的缓解未经手术治疗的主动脉缩窄的方法。主动脉瘤和再缩窄的发生率较低,可能与球囊大小有关。这一早期经验令人鼓舞,但在该方法被广泛用于治疗主动脉缩窄之前,还需要长期结果和更多经验。