Mei Hongxiang, Wu Yumeng, Feng Qingchen, Li Xingjian, Zhou Jiawei, Jiang Fulin, Huang Shishu, Li Juan
State Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Ann Transl Med. 2023 Jan 15;11(1):9. doi: 10.21037/atm-22-3323. Epub 2023 Jan 12.
The mechanisms and effects of the interplay between the nerves and skeleton remain a popular research topic. This study aimed to analyze and evaluate publications on nerve-bone interactions using bibliometrics and to identify the state of the art of current research, hotspots, and future directions.
This study included 1989 articles and reviews from the Web of Science Core Collection (WoSCC) published from January 1, 1991, to June 22, 2022. The Bibliometrix package of R 4.2.0 (The R Foundation for Statistical Computing, Vienna, Austria) was used to analyze basic information about the publications, including the annual number of publications, institution analysis, author influence analysis, journal analysis, and the national cooperation network. We also used CiteSpace 5.8.R3 for bibliometric analysis, including co-occurrence, co-citation, and cluster analysis.
We discovered a significant increase in the number of articles on nerve-bone interactions published over the last 10 years. The most active country and institution were the United States and the University of Minnesota, respectively. In terms of journals and cocited journals, was ranked highest with respect to the number of publications, while was ranked highest among cited journals. Wang Lei was the author with the most publications, and Bjurholm A was the most cited author. The analysis of references and keywords revealed that the impact of nerve- and neuromodulation-related factors on stem cell differentiation was a persistently hot topic. Osteoarthritis, neuropeptide Y, and osteoclastogenic process are likely to be the next era of research hotspots. The neurovascular crosstalk within bone has received great attention, especially in skeletal diseases, which may provide potential targets for future treatments.
We used a bibliometric method to provide an efficient, objective, and comprehensive assessment of existing research about the interplay between the skeletal and nervous systems and to accurately identify hotspots and research frontiers, providing valuable information for future research.
神经与骨骼之间相互作用的机制和影响仍然是一个热门的研究课题。本研究旨在利用文献计量学分析和评估关于神经-骨相互作用的出版物，并确定当前研究的现状、热点和未来方向。
本研究纳入了1991年1月1日至2022年6月22日发表在科学引文索引核心合集（WoSCC）中的1989篇文章和综述。使用R 4.2.0的Bibliometrix软件包（奥地利维也纳的R统计计算基金会）分析出版物的基本信息，包括年度出版物数量、机构分析、作者影响力分析、期刊分析和国家合作网络。我们还使用CiteSpace 5.8.R3进行文献计量分析，包括共现分析、共被引分析和聚类分析。
我们发现过去10年中发表的关于神经-骨相互作用的文章数量显著增加。最活跃的国家和机构分别是美国和明尼苏达大学。在期刊和被共引期刊方面，《》在出版物数量方面排名最高，而在被引期刊中《》排名最高。王磊是发表文章最多的作者，而Bjurholm A是被引次数最多的作者。参考文献和关键词分析表明，神经和神经调节相关因素对干细胞分化的影响一直是热点话题。骨关节炎、神经肽Y和破骨细胞生成过程可能是下一个研究热点时代。骨内的神经血管相互作用受到了极大关注，特别是在骨骼疾病中，这可能为未来治疗提供潜在靶点。
我们使用文献计量学方法对骨骼系统和神经系统之间相互作用的现有研究进行了高效、客观和全面的评估，并准确识别了热点和研究前沿，为未来研究提供了有价值的信息。
