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使用普乐施达(PuraStat)与内镜下止血夹联合方式治疗急性胃肠道出血的内镜止血治疗

Endoscopic Hemostatic Treatment for Acute Gastrointestinal Bleeding by Combined Modality Therapy with PuraStat and Endoscopic Hemoclips.

作者信息

Kubo Kimitoshi, Hayasaka Shuhei, Tanaka Ikko

机构信息

Department of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Japan.

出版信息

Case Rep Gastroenterol. 2023 Feb 7;17(1):89-95. doi: 10.1159/000528896. eCollection 2023 Jan-Dec.

DOI:10.1159/000528896
PMID:36760466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9906041/
Abstract

Acute gastrointestinal bleeding (AGIB) is a common condition leading to hospitalization and is associated with significant morbidity and mortality. Various endoscopic treatments have been reported for AGIB, while its endoscopic hemostasis treatment by combined modality with PuraStat and endoscopic hemoclips remains less well documented. We report 6 cases of AGIB, i.e., 5 cases of ulcer bleeding and 1 case of ruptured gastric varices in 3 males and 3 females aged 49-97 years (mean age, 77 years), 2 and 1 of whom had been on antithrombotic drugs and nonsteroidal anti-inflammatory drugs, respectively, with 2 of these found to be in critical condition with hemorrhagic shock. Types of bleeding treated included oozing bleeding from visible vessels ( = 3), spurting bleeding from visible vessels ( = 2) and from gastric varices ( = 1). In all cases, complete hemostasis was achieved with no rebleeding. To our knowledge, this report represents a valuable addition to the AGIB literature describing endoscopic hemostasis by combined modality therapy with PuraStat and endoscopic hemoclips.

摘要

急性胃肠道出血(AGIB)是一种导致住院的常见病症,且与显著的发病率和死亡率相关。已有多种内镜治疗方法用于AGIB的报道,然而其采用PuraStat与内镜止血夹联合方式进行内镜止血治疗的相关文献报道较少。我们报告了6例AGIB患者,即5例溃疡出血和1例胃静脉曲张破裂出血,患者年龄在49 - 97岁之间(平均年龄77岁),男女各3例,其中分别有2例和1例曾服用抗血栓药物和非甾体类抗炎药,其中2例处于失血性休克的危急状态。治疗的出血类型包括可见血管渗血(3例)、可见血管喷血(2例)以及胃静脉曲张出血(1例)。所有病例均实现了完全止血且未再出血。据我们所知,本报告为AGIB文献增添了有价值的内容,描述了采用PuraStat与内镜止血夹联合方式进行内镜止血治疗的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e265/9906041/f1352bac6591/crg-2022-0017-0001-528896_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e265/9906041/f2a328254d9b/crg-2022-0017-0001-528896_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e265/9906041/996982c41cae/crg-2022-0017-0001-528896_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e265/9906041/f1352bac6591/crg-2022-0017-0001-528896_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e265/9906041/f2a328254d9b/crg-2022-0017-0001-528896_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e265/9906041/996982c41cae/crg-2022-0017-0001-528896_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e265/9906041/f1352bac6591/crg-2022-0017-0001-528896_f3.jpg

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2
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Endoscopy. 2021 Aug;53(8):850-868. doi: 10.1055/a-1496-8969. Epub 2021 Jun 1.
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