Hu Yue, Zhang Xianqin, Deng Shanshan, Yue Changwu, Jia Xu, Lyu Yuhong
Yan'an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan'an University, Yan'An, China.
Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, China.
Front Microbiol. 2023 Jan 25;14:1049917. doi: 10.3389/fmicb.2023.1049917. eCollection 2023.
() is a Gram-negative opportunistic pathogen widely attached to the surface of medical instruments, making it one of the most common pathogens of nosocomial infection, and often leading to cross-infection and co-infection. Due to the extensive antibiotic and pan-resistance, infection is facing fewer treatment options in the clinic. Therefore, the prevention and treatment of infection have become a tricky global problem. The requirement for research and development of the new strategy is urgent. Now, non-antibiotic treatment strategies are urgently needed. This review describes the research on vaccines and antibacterial adjuvants, discusses the advantages and disadvantages of different candidate vaccines tested and , especially subunit protein vaccines, and shows the antibacterial efficacy of adjuvant drugs in monotherapy.
（）是一种革兰氏阴性机会致病菌，广泛附着于医疗器械表面，使其成为医院感染最常见的病原体之一，并经常导致交叉感染和合并感染。由于广泛的抗生素耐药性和泛耐药性，（）感染在临床上面临的治疗选择越来越少。因此，（）感染的预防和治疗已成为一个棘手的全球性问题。对新策略研发的需求迫在眉睫。目前，迫切需要非抗生素治疗策略。本综述描述了（）疫苗和抗菌佐剂的研究，讨论了在（）和（）中测试的不同候选疫苗，特别是亚单位蛋白疫苗的优缺点，并展示了佐剂药物在单一疗法中的抗菌效果。
