老年人群接种流感灭活疫苗后面部外周瘫痪的风险。

Risk of peripheral facial palsy following parenteral inactivated influenza vaccination in the elderly Chinese population.

机构信息

Immunization Center, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.

Immunization Center, Ninghai County Center for Disease Control and Prevention, Ningbo, China.

出版信息

Front Public Health. 2023 Jan 24;11:1047391. doi: 10.3389/fpubh.2023.1047391. eCollection 2023.

DOI:10.3389/fpubh.2023.1047391

PMID:36761129

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9902766/

Abstract

BACKGROUND

Concern about the risk of peripheral facial palsy (PFP) following vaccination is one reason for hesitancy in influenza vaccination. However, the association between the flu vaccine and PFP is still controversial, and further evidence is urgently needed.

METHODS

This self-controlled case series study evaluated PFP risk following inactivated influenza vaccine in the elderly using a large linked database in Ningbo, China. Relative incidence ratios (RIRs) and 95% confidence intervals (CIs) estimated using conditional Poisson regression were utilized to determine whether the risk of PFP was increased after vaccination.

RESULTS

This study included 467 episodes, which occurred in 244 females and 220 males. One hundred twenty-four episodes happened within 1-91 days after vaccination, accounting for 26.7%. The adjusted RIRs within 1-30 days, 31-60 days, 61-91 days, and 1-91 days after influenza vaccination were 0.95 (95% CI 0.69-1.30), 1.08 (95% CI 0.78-1.49), 1.01 (95% CI 0.70-1.45), and 1.00 (95% CI 0.81-1.24), respectively. Similar results were found in subgroup analyses and sensitivity analyses.

CONCLUSIONS

Influenza vaccination does not increase PFP risk in the elderly population. This finding provides evidence to overcome concerns about facial paralysis after influenza vaccination.

摘要

背景

对接种流感疫苗后出现周围性面瘫（PFP）风险的担忧是流感疫苗接种犹豫的原因之一。然而，流感疫苗与 PFP 之间的关联仍存在争议，迫切需要进一步的证据。

方法

本自我对照病例系列研究使用中国宁波的一个大型关联数据库评估了老年人接种灭活流感疫苗后发生 PFP 的风险。使用条件泊松回归估计相对发病率比（RIR）和 95%置信区间（CI），以确定接种疫苗后 PFP 的风险是否增加。

结果

本研究共纳入 467 例病例，其中 244 例为女性，220 例为男性。124 例病例发生在接种后 1-91 天内，占 26.7%。接种后 1-30 天、31-60 天、61-91 天和 1-91 天的调整后 RIR 分别为 0.95（95%CI 0.69-1.30）、1.08（95%CI 0.78-1.49）、1.01（95%CI 0.70-1.45）和 1.00（95%CI 0.81-1.24）。亚组分析和敏感性分析也得到了类似的结果。