NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Front Endocrinol (Lausanne). 2023 Jan 25;14:1124027. doi: 10.3389/fendo.2023.1124027. eCollection 2023.
BACKGROUND: Nanomaterials have recently been shown to have a considerable advantage in promoting wound healing in diabetic patients or animal models. However, no bibliometric analysis has been conducted to evaluate global scientific production. Herein, this study aimed to summarize the current characteristics, explore research trends, and clarify the direction of nanomaterials and diabetic wound healing in the future. METHODS: Relevant publications from 2011 to 2021 were collected from the Web of Science Core Collection on October 3, 2022. VOSviewer, CiteSpace, bibliometrix-R package, Origin 2021, and Microsoft Excel 2019 were used for bibliometric and visualization analyses. RESULTS: We identified 409 publications relating to nanomaterials and diabetic wound healing. The number of annual productions remarkably increased from 2011 to 2021, with China and Shanghai Jiao Tong University being the most productive. The most prolific authors were Hasan Anwarul. The leading journal was the International Journal of Biological Macromolecules, with 22 publications. The most popular keywords were "nanoparticles," "delivery," "," "electrospinning," "angiogenesis," and "antibacterial." Keyword burst analysis showed "cerium oxide," "matrix metalloproteinase 9," "composite nanofiber," "hif 1 alpha," and "oxide nanoparticle" were emerging research hotspots. CONCLUSION: We found there has been a great progress in the application of nanomaterials in diabetic wound healing from 2011 to 2021. Although many researchers and institutions from different countries or regions contributed contributed to publications, it will be helpful or the development of this field if the degree of international cooperation can be enhanced. In the future, nanomaterials with powerful antioxidant and antibacterial qualities and promoting angiogenesis are the research hotspots.
背景:纳米材料在促进糖尿病患者或动物模型的伤口愈合方面具有显著优势,最近已得到证实。然而,尚未有文献计量分析来评估全球科学产出。本研究旨在总结当前特点,探索研究趋势,并阐明纳米材料和糖尿病伤口愈合的未来方向。
方法:于 2022 年 10 月 3 日,从 Web of Science 核心合集收集了 2011 年至 2021 年相关出版物。使用 VOSviewer、CiteSpace、bibliometrix-R 包、Origin 2021 和 Microsoft Excel 2019 进行文献计量和可视化分析。
结果:共确定了 409 篇与纳米材料和糖尿病伤口愈合相关的文献。从 2011 年到 2021 年,年出版物数量显著增加,中国和上海交通大学是最具生产力的国家。最有影响力的作者是 Hasan Anwarul。领先的期刊是《国际生物大分子杂志》,有 22 篇出版物。最热门的关键词是“纳米粒子”、“输送”、“电纺”、“血管生成”和“抗菌”。关键词突发分析表明,“氧化铈”、“基质金属蛋白酶 9”、“复合纳米纤维”、“hif 1 alpha”和“氧化物纳米粒子”是新兴的研究热点。
结论:我们发现,2011 年至 2021 年,纳米材料在糖尿病伤口愈合中的应用取得了重大进展。尽管来自不同国家或地区的许多研究人员和机构都为出版物做出了贡献,但如果能提高国际合作程度,将有助于该领域的发展。未来,具有强大抗氧化和抗菌特性以及促进血管生成的纳米材料将是研究热点。
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