Wei Yongyi, Gao Ke, Sun Yidong, Sheng Qing, Guo Jianjun
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Int J Mol Sci. 2025 Jun 27;26(13):6230. doi: 10.3390/ijms26136230.
Neurological diseases, which include various neurodegenerative disorders, not only impair patients' physical health but also impact their psychological and social functions. It is particularly urgent to seek effective prevention and treatment strategies for neurological diseases. Fructus (AOF), a traditional Chinese medicinal herb, has been widely used in treating urinary, digestive, and neurological disorders. Contemporary medical research has demonstrated that AOF exerts neuroprotective effects through multiple mechanisms, including by inhibiting neuronal apoptosis, alleviating neuroinflammation, reducing oxidative stress, and regulating nerve cell dynamic balance. In recent years, substantial advancements have been achieved in investigations concerning the neuroprotective effects and underlying mechanisms of AOF, alongside significant breakthroughs in its clinical applications. This review systematically summarizes the neuroprotective effects of AOF and delineates its clinical applications, thereby offering valuable reference and guidance for the prevention and treatment of neurological diseases using AOF.
神经系统疾病，包括各种神经退行性疾病，不仅损害患者的身体健康，还会影响其心理和社会功能。寻求有效的神经系统疾病预防和治疗策略尤为紧迫。山茱萸（AOF），一种传统中药，已被广泛用于治疗泌尿系统、消化系统和神经系统疾病。当代医学研究表明，AOF通过多种机制发挥神经保护作用，包括抑制神经元凋亡、减轻神经炎症、降低氧化应激和调节神经细胞动态平衡。近年来，关于AOF神经保护作用及其潜在机制的研究取得了重大进展，其临床应用也有显著突破。本综述系统总结了AOF的神经保护作用并阐述了其临床应用，从而为使用AOF预防和治疗神经系统疾病提供有价值的参考和指导。
