2002 年至 2021 年肠道微生物群与 MAFLD 之间关联的新兴趋势和热点：文献计量分析。

BACKGROUND: The prevalence of metabolic associated fatty liver disease (MAFLD) presented a booming growth over recent years in the whole world. MAFLD was associated with a higher risk of end-stage liver disease, hepatocellular carcinoma and liver transplantation. Accumulating evidence indicated that gut microbiota and MAFLD were interrelated and interacted with each other. However, to the knowledge of the authors, no bibliometric quantitative analysis has been carried out to evaluate the links between the gut microbiota and MAFLD. This study aimed to use bibliometric analysis to evaluate current publication trends and hotspots in the links between the gut microbiota and MAFLD, in order to advance research in this field. METHODS: The articles regarding the links between gut microbiota and MAFLD from 2002 to 2021 were identified from the Science Citation Index-Expanded of Web of Science Core Collection. CiteSpace software, Vosviewer, the R package "bibliometrix" and the Online Analysis Platform of Literature Metrology were used to analyze current publication trends and hotspots in this field. RESULTS: A total of 707 articles were retrieved regarding the links between gut microbiota and MAFLD from 2002 to 2021. The USA occupied the leading role until 2015 and the dominance of China started in 2016. The USA was the most frequently involved country in international cooperation. Shanghai Jiao Tong University was the most productive institution. Ina Bergheim was the most productive author, publishing 14 articles. The co-citation keywords cluster label displayed ten main clusters: probiotics, bile acid, immune function, adolescents, nutritional genomics, high fat diet, systems biology, lipopolysaccharides, phosphatidylcholine, and oxidative stress. Keyword bursts analysis indicated that diet induced obesity, metabolic syndrome, ppar alpha, and lactobacillus were the research hotspots with high strength. CONCLUSION: The number of publications covering the links of gut microbiota and MAFLD increased dramatically in the past decade and especially became exponential growth in the last 3 years. Probiotics and bile acid will be the research direction of great importance in the etiology and novel treatment for MAFLD. This study provided systematic information and instructive assistance for future research work, that helped to discover the mechanisms and new treatments of MAFLD.

背景：代谢相关脂肪性肝病（MAFLD）的患病率近年来在全球范围内呈爆发式增长。MAFLD 与终末期肝病、肝细胞癌和肝移植的风险增加有关。越来越多的证据表明，肠道微生物群与 MAFLD 相互关联并相互作用。然而，据作者所知，尚未进行生物计量学定量分析来评估肠道微生物群与 MAFLD 之间的联系。本研究旨在使用文献计量分析评估肠道微生物群与 MAFLD 之间联系的当前研究趋势和热点，以推动该领域的研究。

方法：从 Web of Science 核心合集的科学引文索引扩展版中确定了 2002 年至 2021 年关于肠道微生物群与 MAFLD 之间联系的文章。使用 CiteSpace 软件、Vosviewer、R 包“bibliometrix”和文献计量学在线分析平台分析该领域的当前研究趋势和热点。

结果：共检索到 2002 年至 2021 年关于肠道微生物群与 MAFLD 之间联系的 707 篇文章。美国在 2015 年之前占据主导地位，中国的主导地位始于 2016 年。美国是国际合作中最常涉及的国家。上海交通大学是最具生产力的机构。伊娜·伯格海姆是最有生产力的作者，发表了 14 篇文章。共被引关键词聚类标签显示了十个主要聚类：益生菌、胆汁酸、免疫功能、青少年、营养基因组学、高脂肪饮食、系统生物学、脂多糖、磷脂酰胆碱和氧化应激。关键词突发分析表明，饮食诱导肥胖、代谢综合征、pparα和乳杆菌是具有高强度的研究热点。

结论：过去十年中，涵盖肠道微生物群与 MAFLD 联系的出版物数量急剧增加，尤其是在过去 3 年中呈指数级增长。益生菌和胆汁酸将成为 MAFLD 病因学和新型治疗的重要研究方向。本研究为未来的研究工作提供了系统的信息和指导帮助，有助于发现 MAFLD 的机制和新疗法。