文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

靶向 NRF2 以促进上皮修复。

Targeting NRF2 to promote epithelial repair.

机构信息

Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.

出版信息

Biochem Soc Trans. 2023 Feb 27;51(1):101-111. doi: 10.1042/BST20220228.

DOI:10.1042/BST20220228
PMID:36762597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9987932/
Abstract

The transcription factor NRF2 is well known as a master regulator of the cellular stress response. As such, activation of NRF2 has gained widespread attention for its potential to prevent tissue injury, but also as a possible therapeutic approach to promote repair processes. While NRF2 activation affects most or even all cell types, its effect on epithelial cells during repair processes has been particularly well studied. In response to tissue injury, these cells proliferate, migrate and/or spread to effectively repair the damage. In this review, we discuss how NRF2 governs repair of epithelial tissues, and we highlight the increasing number of NRF2 targets with diverse roles in regulating epithelial repair.

摘要

转录因子 NRF2 作为细胞应激反应的主要调节因子而广为人知。因此，NRF2 的激活因其预防组织损伤的潜力以及促进修复过程的可能性而受到广泛关注。虽然 NRF2 的激活会影响大多数甚至所有细胞类型，但它在修复过程中对上皮细胞的影响已得到特别深入的研究。在组织损伤的情况下，这些细胞增殖、迁移和/或扩散，以有效地修复损伤。在这篇综述中，我们讨论了 NRF2 如何控制上皮组织的修复，并强调了越来越多的 NRF2 靶标在调节上皮修复中具有多种作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2e9/9987932/3c4e3d9b8dea/BST-51-101-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2e9/9987932/cc5c62452fc5/BST-51-101-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2e9/9987932/3c4e3d9b8dea/BST-51-101-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2e9/9987932/cc5c62452fc5/BST-51-101-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2e9/9987932/3c4e3d9b8dea/BST-51-101-g0002.jpg

相似文献

[1]
Targeting NRF2 to promote epithelial repair.

Biochem Soc Trans. 2023-2-27

[2]
Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.

Am J Nephrol. 2017

[3]
Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells.

Diabetes. 2018-10-23

[4]
p62/SQSTM1 protects against cisplatin-induced oxidative stress in kidneys by mediating the cross talk between autophagy and the Keap1-Nrf2 signalling pathway.

Free Radic Res. 2019-7-8

[5]
Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating the kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis.

Int J Mol Med. 2016-10

[6]
Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.

J Biol Chem. 2017-10-13

[7]
Targeting Keap1 by miR-626 protects retinal pigment epithelium cells from oxidative injury by activating Nrf2 signaling.

Free Radic Biol Med. 2019-8-22

[8]
Protective effects of pyrroloquinoline quinine against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway.

Int Immunopharmacol. 2019-7

[9]
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway.

Mol Cell Biol. 2020-6-15

[10]
NF-κB and Keap1 Interaction Represses Nrf2-Mediated Antioxidant Response in Rabbit Hemorrhagic Disease Virus Infection.

J Virol. 2020-5-4

引用本文的文献

[1]
The ferroptotic effect of NRF2-GCLM signaling axis derived by radiotherapy of esophageal squamous cell cancer: the vivo study.

Sci Rep. 2025-7-24

[2]
Platelet-Released Growth Factors (PRGFs) Activate NRF2-ARE and Modulate Inflammatory Response in an NRF2-Dependent Manner in Primary Human Keratinocytes.

J Cosmet Dermatol. 2025-5

[3]
Screening and Antioxidant Activities Evaluation of Peptides From Abalone ( Ino).

Food Sci Nutr. 2025-2-9

[4]
Nrf-2 as a novel target in radiation induced lung injury.

Heliyon. 2024-4-10

[5]
Mechanism of Nrf2 in the treatment of ulcerative colitis via regulating macrophage polarization.

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023-11-28

[6]
Targeting Signalling Pathways in Chronic Wound Healing.

Int J Mol Sci. 2023-12-19

本文引用的文献

[1]
Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis.

Matrix Biol. 2022-11

[2]
Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair.

Cell Rep. 2022-11-8

[3]
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.

Antioxidants (Basel). 2022-9-14

[4]
Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis.

J Invest Dermatol. 2023-2

[5]
A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.

Nat Commun. 2022-5-19

[6]
Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway.

Oxid Med Cell Longev. 2022

[7]
Inhibition of nuclear factor (erythroid-derived 2)-like 2 promotes hepatic progenitor cell activation and differentiation.

NPJ Regen Med. 2021-5-26

[8]
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.

Hepatology. 2021-8

[9]
Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications.

Free Radic Biol Med. 2021-5-20

[10]
Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis.

Nucleic Acids Res. 2021-4-19

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索