Moradi Nariman, Fadaei Reza, Roozbehkia Maryam, Nourbakhsh Mitra, Nourbakhsh Mona, Razzaghy-Azar Maryam, Larijani Bagher
Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Metabolic Disorders Research Center, Endocrinology and Metabolism, Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Lab Med. 2023 Sep 5;54(5):457-463. doi: 10.1093/labmed/lmac152.
Two newly discovered adipokines, including Meteorin-like protein (Metrnl) and asprosin, have been implicated in glucose and insulin metabolism. This study aimed to investigate the associations of these adipokines with obesity in children and adolescents.
This study was performed on 35 normal-weight children and 35 children with obesity. Anthropometric and biochemical parameters were determined. Serum concentrations of Metrnl, asprosin, and insulin were measured using enzyme-linked immunosorbent assay.
Metrnl level was significantly lower in obese children than normal-weight children. Additionally, Metrnl was negatively correlated with body mass index (BMI), insulin, waist-to-hip ratio, and homeostatic model assessment of insulin resistance (HOMA-IR). Our results also revealed that circulating asprosin levels were significantly increased in obese children compared to the control subjects and were positively correlated with BMI, insulin, HOMA-IR, cholesterol, and LDL-C.
Obesity is accompanied by significant alterations in Metrnl and asprosin and therefore these adipokines, especially Metrnl, are suggested as new promising therapeutic targets for obesity and its associated metabolic imbalances.
两种新发现的脂肪因子，即类陨石蛋白（Metrnl）和脂联素，已被证明与葡萄糖和胰岛素代谢有关。本研究旨在探讨这些脂肪因子与儿童和青少年肥胖的关系。
本研究对35名正常体重儿童和35名肥胖儿童进行。测定人体测量和生化参数。采用酶联免疫吸附测定法测量血清中Metrnl、脂联素和胰岛素的浓度。
肥胖儿童的Metrnl水平显著低于正常体重儿童。此外，Metrnl与体重指数（BMI）、胰岛素、腰臀比和胰岛素抵抗稳态模型评估（HOMA-IR）呈负相关。我们的结果还显示，与对照组相比，肥胖儿童的循环脂联素水平显著升高，且与BMI、胰岛素、HOMA-IR、胆固醇和低密度脂蛋白胆固醇呈正相关。
肥胖伴随着Metrnl和脂联素的显著变化，因此这些脂肪因子，尤其是Metrnl，被认为是肥胖及其相关代谢失衡的新的有前景的治疗靶点。
