[5,5]-氧杂螺内酯的菲烷类化合物的立体发散性构建。
Stereodivergent Construction of [5,5]-Oxaspirolactones of Phainanoids.
机构信息
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China.
出版信息
J Org Chem. 2023 Mar 17;88(6):3987-3991. doi: 10.1021/acs.joc.2c03091. Epub 2023 Mar 7.
PMID:36883240
Abstract
A stereodivergent synthesis of [5,5]-oxaspirolactones of phainanoids is presented herein. Through precisely tuning the inherent substitution differences on cyclopropanol, a palladium-catalyzed cascade carbonylative lactonization enables the stereodivergent synthesis of [5,5]-oxaspirolactones of phainanoids.
摘要
本文呈现了一种[5,5]-氧杂螺内酯的立体发散合成方法。通过精确调节环丙醇上固有的取代差异，钯催化的级联羰基化内酯化反应能够实现[5,5]-氧杂螺内酯的立体发散合成。
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