Dines Hannah R, Nixon Jennifer, Lockey Sarah J, Herbert Adam J, Kipps Courtney, Pedlar Charles R, Day Stephen H, Heffernan Shane M, Antrobus Mark R, Brazier Jon, Erskine Robert M, Stebbings Georgina K, Hall Elliott C R, Williams Alun G
Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom.
School of Medicine, Facutly of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford, United Kingdom.
J Strength Cond Res. 2023 Apr 1;37(4):799-805. doi: 10.1519/JSC.0000000000004291. Epub 2022 Jun 7.
Dines, HR, Nixon, J, Lockey, SJ, Herbert, AJ, Kipps, C, Pedlar, CR, Day, SH, Heffernan, SM, Antrobus, MR, Brazier, J, Erskine, RM, Stebbings, GK, Hall, ECR, and Williams, AG. Collagen gene polymorphisms previously associated with resistance to soft-tissue injury are more common in competitive runners than nonathletes. J Strength Cond Res 37(4): 799-805, 2023-Single-nucleotide polymorphisms (SNPs) of collagen genes have been associated with soft-tissue injury and running performance. However, their combined contribution to running performance is unknown. We investigated the association of 2 collagen gene SNPs with athlete status and performance in 1,429 Caucasian subjects, including 597 competitive runners (354 men and 243 women) and 832 nonathletes (490 men and 342 women). Genotyping for COL1A1 rs1800012 (C > A) and COL5A1 rs12722 (C > T) SNPs was performed by a real-time polymerase chain reaction. The numbers of "injury-resistant" alleles from each SNP, based on previous literature (rs1800012 A allele and rs12722 C allele), were combined as an injury-resistance score (RScore, 0-4; higher scores indicate injury resistance). Genotype frequencies, individually and combined as an RScore, were compared between cohorts and investigated for associations with performance using official race times. Runners had 1.34 times greater odds of being rs12722 CC homozygotes than nonathletes (19.7% vs. 15.5%, p = 0.020) with no difference in the rs1800012 genotype distribution ( p = 0.659). Fewer runners had an RScore 0 of (18.5% vs. 24.7%) and more had an RScore of 4 (0.6% vs. 0.3%) than nonathletes ( p < 0.001). Competitive performance was not associated with the COL1A1 genotype ( p = 0.933), COL5A1 genotype ( p = 0.613), or RScore ( p = 0.477). Although not associated directly with running performance among competitive runners, a higher combined frequency of injury-resistant COL1A1 rs1800012 A and COL5A1 rs12722 C alleles in competitive runners than nonathletes suggests these SNPs may be advantageous through a mechanism that supports, but does not directly enhance, running performance.
迪内斯、HR、尼克松、J、洛基、SJ、赫伯特、AJ、基普斯、C、佩德lar、CR、戴、SH、赫弗南、SM、安特罗布斯、MR、布雷齐尔、J、厄斯金、RM、斯特宾斯、GK、霍尔、ECR和威廉姆斯、AG。先前与软组织损伤抗性相关的胶原蛋白基因多态性在竞技跑步者中比非运动员更常见。《力量与体能研究杂志》37(4): 799 - 805, 2023 - 胶原蛋白基因的单核苷酸多态性(SNP)与软组织损伤和跑步表现有关。然而，它们对跑步表现的综合贡献尚不清楚。我们在1429名白种人受试者中调查了2种胶原蛋白基因SNP与运动员身份和表现的关联，其中包括597名竞技跑步者(354名男性和243名女性)和832名非运动员(490名男性和342名女性)。通过实时聚合酶链反应对COL1A1 rs1800012 (C > A)和COL5A1 rs12722 (C > T) SNP进行基因分型。根据先前的文献(rs1800012 A等位基因和rs12722 C等位基因)，将每个SNP的“抗损伤”等位基因数量合并为抗损伤评分(RScore，0 - 4；分数越高表明抗损伤能力越强)。在队列之间比较个体基因型频率以及合并为RScore后的频率，并使用官方比赛时间调查与表现的关联。跑步者成为rs12722 CC纯合子的几率是非运动员的1.34倍(19.7%对15.5%，p = 0.020)，而rs1800012基因型分布没有差异(p = 0.659)。与非运动员相比，跑步者中RScore为0的较少(18.5%对24.7%)，RScore为4的较多(0.6%对0.3%)(p < 0.001)。竞技表现与COL1A1基因型(p = 0.933)、COL5A1基因型(p = 0.613)或RScore(p = 0.477)无关。尽管在竞技跑步者中与跑步表现没有直接关联，但竞技跑步者中抗损伤的COL1A1 rs1800012 A和COL5A1 rs12722 C等位基因的联合频率高于非运动员，这表明这些SNP可能通过一种支持但不直接增强跑步表现的机制具有优势。
