Borkent Jenny, Ioannou Magdalini, Folkertsma Tessa S, Wardenaar Klaas J, Haarman Bartholomeus C M, van Goor Harry, Sommer Iris E C, Bourgonje Arno R
University of Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells & Systems, Groningen, the Netherlands.
University of Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells & Systems, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands.
Psychiatry Res. 2023 Mar;321:115075. doi: 10.1016/j.psychres.2023.115075. Epub 2023 Jan 26.
Schizophrenia spectrum disorders (SSD) have been linked to oxidative stress (OS). Recent findings from our group show that serum free thiols (R-SH, sulfhydryl groups) can function as an accurate biomarker of systemic OS, since they are readily oxidized by reactive species (ROS), thereby serving as potent antioxidants. The aim of this study is to investigate if reduced R-SH levels can be demonstrated in recently diagnosed patients with SSD compared to healthy controls (HC). In this study, 102 patients with recently diagnosed SSD (< three years), and 42 HC were included. Levels of R-SH were quantified and studied for correlations with age, C-reactive protein (CRP) as proxy of inflammation as well as body mass index (BMI) and total cholesterol as indices of metabolic health. R-SH levels were significantly lower in patients when compared to HC. When correcting for age the difference was borderline significant (p=0.05). Moreover, R-SH correlated significantly with age (r = -0.29) and CRP (r = -0.29) in patients with SSD, but not in the HC. R-SH levels are reduced in SSD as compared to HC and correlate negatively with CRP and age in SSD. Future studies are required to further investigate R-SH and its role in SSD.
精神分裂症谱系障碍（SSD）与氧化应激（OS）有关。我们团队最近的研究结果表明，血清游离硫醇（R-SH，巯基）可作为全身OS的准确生物标志物，因为它们很容易被活性物质（ROS）氧化，从而起到有效的抗氧化剂作用。本研究的目的是调查与健康对照（HC）相比，新诊断的SSD患者是否能显示出R-SH水平降低。在本研究中，纳入了102例新诊断的SSD患者（<3年）和42例HC。对R-SH水平进行定量，并研究其与年龄、作为炎症指标的C反应蛋白（CRP）以及作为代谢健康指标的体重指数（BMI）和总胆固醇的相关性。与HC相比，患者的R-SH水平显著降低。校正年龄后，差异接近显著（p=0.05）。此外，在SSD患者中，R-SH与年龄（r=-0.29）和CRP（r=-0.29）显著相关，但在HC中不相关。与HC相比，SSD患者的R-SH水平降低，且在SSD中与CRP和年龄呈负相关。需要进一步的研究来进一步调查R-SH及其在SSD中的作用。
