Hennebert P
Laboratoire de Pharmacie Galénique, Université Catholique de Louvain, Brussels, Belgium.
Biomaterials. 1987 Sep;8(5):346-52. doi: 10.1016/0142-9612(87)90004-4.
A general solution of the diffusion equation for gas in polymers is developed by a numerical method. This solution allows diffusion to be calculated in all cases, by gas desorption after an incomplete adsorption, which is not the case for analytical solutions. When the analytical solutions are valid, both types of solution give identical results. The effect of equivalent sterilization treatment at different temperatures and gas concentrations on formaldehyde residuals in 9 polymers is calculated. High temperature gives lower residual content. Short sterilization times at high gas concentration produce a higher residual content at the end of the adsorption and a lower residual content during desorption than longer sterilization times with lower gas concentration. This is due to sharper gradients of diffusant in the polymer.
采用数值方法推导了气体在聚合物中扩散方程的通解。该解能计算所有情况下的扩散，包括不完全吸附后的气体解吸情况，而解析解则无法做到这一点。当解析解有效时，两种解给出的结果相同。计算了不同温度和气体浓度下等效灭菌处理对9种聚合物中甲醛残留量的影响。高温下残留量较低。高气体浓度下较短的灭菌时间在吸附结束时产生较高的残留量，而在解吸过程中残留量低于低气体浓度下较长灭菌时间的情况。这是由于聚合物中扩散剂的梯度更陡。
