脑类器官可修复皮质损伤。

Brain organoids restore cortical damage.

作者信息

Altinisik Nazlican, Rathinam Dhanasekaran, Tran Minh, Gopalakrishnan Jay

机构信息

Institute of Human Genetics, University Hospital, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany.

出版信息

Cell Stem Cell. 2023 Mar 2;30(3):241-242. doi: 10.1016/j.stem.2023.01.012. Epub 2023 Feb 9.

DOI:10.1016/j.stem.2023.01.012

PMID:36764295

Abstract

Cortical damage is irreparable and poses a challenge to regenerative medicine. Whether brain organoids can compensate for injured brain regions remains unclear. In this issue of Cell Stem Cell, Jgamadze et al. report that human forebrain organoids transplanted into the rat visual system show long-term structural connectivity and the restoration of visual function following lesions.

摘要

皮质损伤是不可修复的，这对再生医学构成了挑战。脑类器官是否能够补偿受损的脑区仍不清楚。在本期《细胞·干细胞》杂志中，贾马泽等人报道称，移植到大鼠视觉系统中的人类前脑类器官在损伤后显示出长期的结构连接性和视觉功能的恢复。