College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, 712 100, China.
Centre for Research in Emerging Tropical Diseases (CRET-D), Department of Zoology, University of Calicut, Malappuram, Kerala, India.
Environ Pollut. 2023 Apr 1;322:121246. doi: 10.1016/j.envpol.2023.121246. Epub 2023 Feb 8.
The adaptive responses to moderate environmental challenges by the biological systems have usually been credited to hormesis. Since the hormetic biphasic dose-response illustrates a prominent pattern towards biological responsiveness, the studies concerning such aspects will get much more significance in risk assessment practices and toxicological evaluation research. From this point of view, the past few epochs have witnessed the extending recognition of the notion concerning hormesis. The extraction of its basic foundations of evolutionary perspectives-along with the probable underlying molecular and cellular mechanisms followed by the practical implications to enhance the quality of life. To get better and more effective output in this regard, the present article has evaluated the various observations of previous investigations. The intent of integrating the novel inferences concerning the hormesis-tempting stressors driven by predominant evolutionary factors for mitigating the adverse impacts that were prompted over frequent and continuous exposure to the various chemical elements. Such inferences can offer extensive insight into the implications concerning the risk assessment of hormesis.
生物系统对适度环境挑战的适应性反应通常归因于毒物兴奋效应。由于毒物兴奋的双相剂量反应呈现出对生物反应性的显著模式，因此关于这些方面的研究在风险评估实践和毒理学评价研究中将变得更加重要。从这个角度来看，过去几个时期见证了对毒物兴奋效应概念的认识不断扩大。从进化角度提取其基本基础-以及可能的潜在分子和细胞机制，随后对提高生活质量的实际影响。为了在这方面获得更好、更有效的结果，本文评估了以前研究的各种观察结果。本研究的目的是整合关于毒物兴奋效应的新推论，这些推论受到主要进化因素驱动的胁迫，以减轻由于频繁和持续暴露于各种化学元素而引起的不利影响。这些推论可以为毒物兴奋效应的风险评估的意义提供广泛的见解。
