Unit of Dermatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
J Cutan Pathol. 2023 May;50(5):420-424. doi: 10.1111/cup.14405. Epub 2023 Mar 8.
The association between acanthosis nigricans (AN) and mycosis fungoides (MF) has rarely been described, but it is known that MF may appear as AN-like vegetating and papillomatous plaques in skin folds, or may be associated with paraneoplastic AN. There have also been recent descriptions of a form of "intertriginous MF" that is characterized by skin fold involvement and the expression of T follicular helper (TFH) markers, and that often has an aggressive course. We describe the case of a 48-year-old man affected by MF associated with AN, whose lesions were characterized by a TFH immunophenotype and the expression of the GATA-3 nuclear master regulator that may be related to a TFH-2 subpopulation or possible disease progression.
黑棘皮症（AN）与蕈样肉芽肿（MF）之间的关联很少被描述，但已知 MF 可能在皮肤褶皱中表现为类似 AN 的增生性和乳头状斑块，或者可能与副肿瘤性 AN 相关。最近也有描述一种“皱褶部 MF”的形式，其特征为皮肤褶皱受累和 T 滤泡辅助（TFH）标志物的表达，且通常具有侵袭性病程。我们描述了一例 48 岁男性患者，患有 MF 伴 AN，其病变特征为 TFH 免疫表型和 GATA-3 核主调控因子的表达，这可能与 TFH-2 亚群或可能的疾病进展有关。
