Cheng Esther, Roy David B, Magro Cynthia M
NewYork Presbyterian Hospital - Weill Cornell Medical Center.
Dermatol Online J. 2015 Jul 15;21(7):13030/qt3sw2t3b8.
Acanthosis nigricans maligna (ANM) is a paraneoplastic phenomenon most commonly associated with visceral adenocarcinoma, in particular, gastric adenocarcinoma. Clinically, AMN is characterized by rapidly progressive symmetrical skin thickening and hyperpigmentation of the intertriginous areas with peripheral acrochorda. The diagnosis is made by a detailed medical work-up for occult malignancies with particular emphasis on endocrinological diseases. We report a 67-year-old man that presented clinically with acanthosis nigricans, in which a subsequent diagnosis of mycosis fungoides was made.
恶性黑棘皮病（ANM）是一种副肿瘤现象，最常与内脏腺癌相关，尤其是胃腺癌。临床上，AMN的特征是迅速进展的对称性皮肤增厚以及有外周皮赘的褶皱部位色素沉着。通过针对隐匿性恶性肿瘤的详细医学检查来做出诊断，尤其要重点排查内分泌疾病。我们报告了一名67岁临床诊断为黑棘皮病的男性患者，随后被诊断为蕈样肉芽肿。
