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[δ-睡眠肽对大鼠和猫大脑皮质癫痫活动的影响]

[Effect of the delta sleep peptide on epileptic activity in the cerebral cortex of rats and cats].

作者信息

Kryzhanovskiĭ G N, Shandra A A, Godlevskiĭ L S, Karpova M N, Mikhaleva I I

出版信息

Biull Eksp Biol Med. 1987 Nov;104(11):582-5.

PMID:3676495
Abstract

In free behaviour experiments on rats it has been shown that the intraperitoneal injection of delta sleep-inducing peptide (DSIP) (100 micrograms/kg) suppressed penicillin-induced relatively moderate epileptic foci which generated spike potentials as well as severe foci with ictal epileptic discharges. In the experiments on cats it was shown that intravenous DSIP injection (100 micrograms/kg) suppressed strychnine-induced epileptic focus and complexes of epileptic foci.

摘要

在对大鼠的自由行为实验中已表明,腹腔注射δ睡眠诱导肽(DSIP)(100微克/千克)可抑制青霉素诱导的相对中度癫痫病灶,这些病灶产生棘波电位以及伴有发作性癫痫放电的严重病灶。在对猫的实验中表明,静脉注射DSIP(100微克/千克)可抑制士的宁诱导的癫痫病灶和癫痫病灶复合体。

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