Department of Otorhinolaryngology, Head and Neck Surgery, University Medicine Halle (Saale), University Hospital Halle (Saale), Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
Sci Rep. 2023 Feb 10;13(1):2413. doi: 10.1038/s41598-023-29422-1.
Objective measurements could improve cochlear implant (CI) fitting, especially for CI users who have difficulty assessing their hearing impressions. In this study, we investigated the electrically evoked mismatch negativity (eMMN) brain potential as a mainly preattentive response to pitch and loudness changes. In an electrophysiological exploratory study with 21 CI users, pitch and loudness cues were presented in controlled oddball paradigms that directly electrically stimulated the CI via software. Out of them 17 valid data sets were analyzed. A pitch cue was produced by changing the stimulating CI electrodes (pairs of adjacent electrodes). A loudness cue originated from changing the stimulation amplitude on one CI electrode. MMN responses were measured unsing clinical electroencephalography recording according to a standard recording protocol. At the group level, significant eMMN responses were elicited for loudness cues and for pitch cues at basal electrode pairs but not at apical electrode pairs. The effect of deviance direction was not significant and no stimulus artifacts were observed. Recording an electrically evoked MMN in response to loudness changes in CI users is generally feasible, and is, therefore, promising to support CI fitting procedures in the future. Detection of pitch cues would require a greater electrode distance between selected electrodes for standard and deviant stimuli, especially in apical regions. A routine clinical setup can be used to measure eMMN.
客观测量可以改善人工耳蜗（CI）的适配，特别是对于那些难以评估听力印象的 CI 用户。在这项研究中，我们研究了电诱发失匹配负波（eMMN）脑电位，作为一种主要的前注意反应，用于探测音高和响度的变化。在一项针对 21 名 CI 用户的电生理探索性研究中，通过软件直接对 CI 进行电刺激，使用控制的Oddball 范式呈现音高和响度线索。其中 17 个有效数据集被分析。音高线索通过改变刺激 CI 的电极（一对相邻电极）来产生。响度线索源于改变一个 CI 电极上的刺激幅度。根据标准记录协议，使用临床脑电图记录测量 MMN 反应。在组水平上，对于响度线索和基底电极对的音高线索，可以引出明显的 eMMN 反应，但不能引出顶点电极对的反应。偏差方向的影响不显著，也没有观察到刺激伪影。在 CI 用户中，记录对响度变化的电诱发 MMN 通常是可行的，因此有望在未来支持 CI 适配程序。检测音高线索需要在选定电极之间有更大的电极距离，以便在标准和偏差刺激中使用，特别是在顶点区域。常规的临床设置可以用于测量 eMMN。
