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APN、hs-CRP 及 APN/hs-CRP 在牙周炎伴发 DAA 中的作用

The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA.

机构信息

Department of Endocrinology, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001, Shanxi Province, China.

Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi Province, China.

出版信息

BMC Oral Health. 2023 Feb 10;23(1):85. doi: 10.1186/s12903-023-02765-x.

DOI:10.1186/s12903-023-02765-x
PMID:36765308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9921664/
Abstract

BACKGROUND

Common chronic infections induced low-grade inflammation has been correlated with atherosclerosis as supported by strong evidence. The balance between pro-and anti-inflammatory factors was exploited to elucidate the effects of chronic periodontitis on diabetes-associated atherosclerosis.

METHODS

Study subjects encompassed 30 SPF male rats randomly divided into four groups: A group (NC), B group (T2DM), C group (CP), D group (DM + CP). After developing the model, blood samples were collected from the angular vein analyze serum APN, hs-CRP, and blood lipid. the carotid artery was isolated for HE staining.

RESULT

Compared with group A, the serum APN in group B, C and D decreased gradually with the progression of the disease. Serum hs-CRP in group B, C and D was significantly increased. At T3, T4 and T5 in group B, C and D, APN/hs-CRP significantly decreased. TC, LDL and TG significantly increased in group B, D; HDL significantly decreased in group C. Carotid artery HE staining showed: compared with group A, different degrees of endothelial defect, destruction of elastic fibers in the middle membrane, disorder of smooth muscle arrangement, and partial dissolution 、 fragmentation and Calcium salt deposition necrosis occurred in group B, C and D.

CONCLUSION

Enhanced systemic inflammation, decreased adiponectin level, and disorganized lipid metabolism with or without type 2 diabetes attributed to local inflammation of periodontitis can result in an imbalance of pro-inflammatory and anti-inflammatory effects. Therefore, it's more meaningful to predict the progression of DAA with anti-inflammatory/pro-inflammatory variation.

摘要

背景

慢性感染引起的低度炎症与动脉粥样硬化有关，这一观点得到了大量证据的支持。通过研究促炎和抗炎因子之间的平衡，可以阐明慢性牙周炎对糖尿病相关动脉粥样硬化的影响。

方法

研究对象包括 30 只 SPF 雄性大鼠，随机分为 4 组：A 组（NC）、B 组（T2DM）、C 组（CP）、D 组（DM+CP）。造模成功后，从眶静脉角采集血样，检测血清 APN、hs-CRP、血脂水平。分离颈动脉行 HE 染色。

结果

与 A 组相比，B、C、D 组血清 APN 逐渐下降，且疾病进展，B、C、D 组血清 hs-CRP 明显升高。B、C、D 组在 T3、T4、T5 时，APN/ hs-CRP 明显降低。B、D 组 TC、LDL、TG 明显升高，C 组 HDL 明显降低。颈动脉 HE 染色显示：与 A 组相比，B、C、D 组不同程度出现内皮损伤、中膜弹力纤维破坏、平滑肌排列紊乱，部分出现溶解、碎裂和钙盐沉积坏死。

结论

有或无 2 型糖尿病的牙周炎局部炎症导致全身炎症增强、脂联素水平降低、脂代谢紊乱，促炎和抗炎作用失衡。因此，抗炎/促炎变化预测 DAA 的进展更有意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/654a395f6fd4/12903_2023_2765_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/308306159aef/12903_2023_2765_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/84423691859d/12903_2023_2765_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/517ff96e77da/12903_2023_2765_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/565a81b5ecec/12903_2023_2765_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/220bbd44e64b/12903_2023_2765_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/9f69ec4881ac/12903_2023_2765_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/654a395f6fd4/12903_2023_2765_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/308306159aef/12903_2023_2765_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/9c43d3bbd7ca/12903_2023_2765_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/84423691859d/12903_2023_2765_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/517ff96e77da/12903_2023_2765_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/565a81b5ecec/12903_2023_2765_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/220bbd44e64b/12903_2023_2765_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/9f69ec4881ac/12903_2023_2765_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904a/9921664/654a395f6fd4/12903_2023_2765_Fig8_HTML.jpg

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