Ding Xueqing, Tan Jinzhen, Meng Jing, Shao Yilei, Shen Meixiao, Dai Cuixia
College of Science, Shanghai Institute of Technology, Shanghai 201418, China.
College of Computer Science, Qufu Normal University, Qufu 276825, China.
Diagnostics (Basel). 2023 Jan 19;13(3):379. doi: 10.3390/diagnostics13030379.
Myopia is a significant cause of visual impairment which may lead to many complications. However, the understanding of the mechanisms of myopia is still limited. In this paper, in order to investigate the development and the treatment of myopia, we analyzed the biological structure parameters of mice eyes, obtained from optical coherence tomography (OCT), and the optical performance of mice eyes calculated using ZEMAX software (ZEMAX Development Corporation, Kirkland, WA, USA) in which the optical model was built on the segment-by-segment optically corrected OCT 3D-images. Time-serial evaluation of three groups of mice eyes (form-deprivation myopia mice eyes, normal mice eyes, and atropine-treated myopia mice eyes) was performed. In addition to the biological structure parameters, imaging performance with the development of root-mean-square wavefront aberration at six filed angles was compared and analyzed. Results show that the biological structure parameters of the eye are closely related to the development of myopia. The peripheral defocus of the retina has a significant impact on inducing myopia, which verifies the new theory of myopia development. The delaying effect of atropine solution on myopia development is shown to verify the therapeutic effect of the medicine. This study provides technical support for the investigation of the myopia mechanism.
近视是导致视力损害的一个重要原因，可能会引发许多并发症。然而，目前对近视发病机制的认识仍然有限。在本文中，为了研究近视的发展及治疗方法，我们分析了通过光学相干断层扫描（OCT）获得的小鼠眼睛的生物结构参数，以及使用ZEMAX软件（美国华盛顿州柯克兰市的ZEMAX开发公司）计算得出的小鼠眼睛的光学性能，其中光学模型是基于逐段光学校正的OCT三维图像构建的。对三组小鼠眼睛（形觉剥夺性近视小鼠眼睛、正常小鼠眼睛和阿托品治疗的近视小鼠眼睛）进行了时间序列评估。除了生物结构参数外，还对六个视场角下随着均方根波前像差发展的成像性能进行了比较和分析。结果表明，眼睛的生物结构参数与近视的发展密切相关。视网膜周边离焦对诱发近视有显著影响，这验证了近视发展的新理论。阿托品溶液对近视发展的延缓作用得以证实，验证了该药物的治疗效果。本研究为近视机制的研究提供了技术支持。
