Ambrogio Francesca, Colagrande Anna, Cascardi Eliano, Grandolfo Mauro, Filotico Raffaele, Foti Caterina, Lupo Carmelo, Casatta Nadia, Ingravallo Giuseppe, Cazzato Gerardo
Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
Section of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.
Diagnostics (Basel). 2023 Jan 29;13(3):495. doi: 10.3390/diagnostics13030495.
Malignant melanoma (MM) is traditionally known as the "great mime" of human pathology, as it is potentially capable of imitating the most disparate neoplasms. It is known that in addition to the more classic histotypes of MM, there are also rare forms, including angiomatoid MM. Similarly, it has been amply demonstrated in the literature that MM is capable of dedifferentiating, losing melanocytic lineage markers, constituting a diagnostic challenge for the pathologist. Although 5 cases of primary angiomatoid MM have been described in the literature, to the best of our knowledge, no cases of dedifferentiated melanoma with pseudo-angiomatoid aspects have ever been described. In this paper, we present a very rare case of partially dedifferentiated MM in which the most dedifferentiated component lost melanocytic lineage immunohistochemical markers and assumed a pseudo-angiomatous morphology. Given the rarity of the case, we carried out a literature review of similar cases described, trying to draw new future perspectives not only about this particular variant of MM but also about the widest field of dedifferentiation/undifferentiation of MM.
恶性黑色素瘤（MM）传统上被称为人类病理学中的“模仿大师”，因为它有可能模仿最不同类型的肿瘤。众所周知，除了更经典的MM组织学类型外，还有罕见的形式，包括血管样MM。同样，文献中也充分证明，MM能够去分化，失去黑素细胞谱系标记，这对病理学家构成了诊断挑战。尽管文献中描述了5例原发性血管样MM，但据我们所知，从未有过具有假血管样特征的去分化黑色素瘤病例的描述。在本文中，我们报告了一例非常罕见的部分去分化MM病例，其中去分化程度最高的成分失去了黑素细胞谱系免疫组化标记，并呈现出假血管样形态。鉴于该病例的罕见性，我们对已描述的类似病例进行了文献综述，试图不仅就MM的这一特殊变体，而且就MM去分化/未分化的更广泛领域得出新的未来观点。
