Cazzato Gerardo, Lospalluti Lucia, Colagrande Anna, Cimmino Antonietta, Romita Paolo, Foti Caterina, Demarco Aurora, Arezzo Francesca, Loizzi Vera, Cormio Gennaro, Sablone Sara, Resta Leonardo, Rossi Roberta, Ingravallo Giuseppe
Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.
Section of Dermatology, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari "Aldo Moro", 70124 Bari, Italy.
Dermatopathology (Basel). 2021 Oct 15;8(4):494-501. doi: 10.3390/dermatopathology8040051.
Dedifferentiated melanoma is a particular form of malignant melanoma with a progressive worsening of the patient's clinical outcome. It is well known that melanoma can assume different histo-morphological patterns, to which specific genetic signatures correspond, sometimes but not always. In this review we address the diagnostic difficulties in correctly recognizing this entity, discuss the major differential diagnoses of interest to the dermatopathologist, and conduct a review of the literature with particular attention and emphasis on the latest molecular discoveries regarding the dedifferentiation/undifferentiation mechanism and more advanced therapeutic approaches.
去分化黑色素瘤是恶性黑色素瘤的一种特殊形式，患者的临床预后会逐渐恶化。众所周知，黑色素瘤可呈现不同的组织形态学模式，有时但并非总是对应特定的基因特征。在本综述中，我们阐述了正确识别该实体时面临的诊断困难，讨论了皮肤病理学家感兴趣的主要鉴别诊断，并对文献进行了综述，特别关注并强调了有关去分化/未分化机制的最新分子发现以及更先进的治疗方法。
