School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Clinic of Nephrology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Cells. 2023 Jan 17;12(3):351. doi: 10.3390/cells12030351.
As we already reported, fibrinogen fucosylation emerged as a prognostic marker of peritoneal membrane function in end-stage renal disease (ESRD) patients on peritoneal dialysis. After a follow-up period of 18 months, we estimated the ability of employed lectins, as well as other biochemical parameters, to serve as mortality predictors in these patients. Following a univariate Cox regression analysis, ferritin, urea clearance, residual diuresis, hyperglycemia, and an increase in the signal intensity obtained with Galanthus nivalis lectin (GNL) emerged as potential mortality predictors, but additional multivariate Cox regression analysis pointed only to glucose concentration and GNL as mortality predictors. Higher signal intensity obtained with GNL in patients that died suggested the importance of paucimannosidic/highly mannosidic N-glycan structures on fibrinogen as factors that are related to unwanted cardiovascular events and all-cause mortality and can possibly be seen as a prediction tool. Altered glycan structures composed of mannose residues are expected to affect the reactivity of mannosylated glycoproteins with mannose-binding lectin and possibly the entire cascade of events linked to this lectin. Since patients with ESRD are prone to cardiovascular complications and the formation of atherosclerotic plaques, one can hypothesize that fibrinogen with increasingly exposed mannose residues may contribute to the unwanted events.
正如我们之前报道的，纤维蛋白原岩藻糖化可作为终末期肾病（ESRD）患者腹膜透析时腹膜功能的预后标志物。经过 18 个月的随访，我们评估了所使用的凝集素以及其他生化参数作为这些患者死亡预测因子的能力。经过单因素 Cox 回归分析，铁蛋白、尿素清除率、残余尿量、高血糖和雪花莲凝集素（GNL）获得的信号强度增加被认为是潜在的死亡预测因子，但进一步的多因素 Cox 回归分析仅指出葡萄糖浓度和 GNL 是死亡预测因子。在死亡患者中 GNL 获得的信号强度较高表明纤维蛋白原上的寡甘露糖/高甘露糖 N-糖链结构作为与不良心血管事件和全因死亡率相关的因素的重要性，并且可能可以作为一种预测工具。由甘露糖残基组成的糖链结构的改变预计会影响甘露糖结合凝集素与甘露糖化糖蛋白的反应性，并且可能会影响与该凝集素相关的整个级联反应。由于 ESRD 患者易发生心血管并发症和动脉粥样硬化斑块的形成，因此可以假设纤维蛋白原上越来越暴露的甘露糖残基可能导致不良事件的发生。
