Department of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
Department of Pulmonology, School of Public Health, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Cells. 2023 Jan 31;12(3):468. doi: 10.3390/cells12030468.
Aquaporins (AQPs) are selective, transmembrane proteins, which are primarily responsible for the transport of water and small molecules. They have been demonstrated to play a key role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer diagnosed in patients in Europe and the USA. The research done so far has provided firm evidence that some AQPs can be biomarkers for various diseases. The objective of this review article is to present a potential role of AQP5 in the development of lung adenocarcinoma. Original papers discussing the involvement of AQP5 in carcinogenesis and containing relevant clinical data were identified. In order to analyze the research material in accordance with PRISMA guidelines, a systematic search of the ScienceDirect, Web of Science, and Pubmed databases was conducted. Out of the total number of 199 papers identified, 14 original articles were subject to analysis. This article presents the pathophysiological role of AQP5 in the biology of lung adenocarcinoma as well as its prognostic value. The analysis substantiates the conclusion that the prognostic value of AQP5 in lung cancer requires further research. Another aim of this paper is to disseminate knowledge about AQPs among clinicians.
水通道蛋白（AQPs）是一种选择性的跨膜蛋白，主要负责水和小分子的运输。它们在癌症的发生和发展中起着关键作用。肺腺癌是欧洲和美国患者中最常见的原发性肺癌。迄今为止的研究提供了确凿的证据，表明一些 AQPs 可以作为各种疾病的生物标志物。本文旨在探讨 AQP5 在肺腺癌发展中的潜在作用。本文讨论了 AQP5 在致癌作用中的作用，并包含了相关的临床数据。为了根据 PRISMA 指南分析研究材料，对 ScienceDirect、Web of Science 和 Pubmed 数据库进行了系统搜索。在总共确定的 199 篇论文中，有 14 篇原始论文进行了分析。本文介绍了 AQP5 在肺腺癌生物学中的病理生理作用及其预后价值。分析证实了 AQP5 在肺癌中的预后价值需要进一步研究的结论。本文的另一个目的是在临床医生中传播关于 AQPs 的知识。
