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产前全氟和多氟烷基物质暴露与后代神经行为问题的关联：一项荟萃分析。

The Association between Prenatal Per- and Polyfluoroalkyl Substances Exposure and Neurobehavioral Problems in Offspring: A Meta-Analysis.

机构信息

Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, China.

Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.

出版信息

Int J Environ Res Public Health. 2023 Jan 17;20(3):1668. doi: 10.3390/ijerph20031668.

DOI:10.3390/ijerph20031668
PMID:36767045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9914055/
Abstract

Exposure to per- and polyfluoroalkyl substances (PFAS) during pregnancy has been suggested to be associated with neurobehavioral problems in offspring. However, current epidemiological studies on the association between prenatal PFAS exposure and neurobehavioral problems among offspring, especially attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), are inconsistent. Therefore, we aimed to study the relationship between PFAS exposure during pregnancy and ADHD and ASD in offspring based on meta-analyses. Online databases, including PubMed, EMBASE, and Web of Science, were searched comprehensively for eligible studies conducted before July 2021. Eleven studies (up to 8493 participants) were included in this analysis. The pooled results demonstrated that exposure to perfluorooctanoate (PFOA) was positively associated with ADHD in the highest quartile group. Negative associations were observed between perfluorooctane sulfonate (PFOS) and ADHD/ASD, including between perfluorononanoate (PFNA) and ASD. There were no associations found between total PFAS concentration groups and neurobehavioral problems. The trial sequential analyses showed unstable results. Our findings indicated that PFOA and PFOS exposure during pregnancy might be associated with ADHD in offspring and that prenatal PFOS and PFNA exposure might be associated with ASD in offspring. According to the limited evidence obtained for most associations, additional studies are required to validate these findings.

摘要

孕期接触全氟和多氟烷基物质（PFAS）与后代神经行为问题有关。然而，目前关于产前 PFAS 暴露与后代神经行为问题（尤其是注意缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD））之间关联的流行病学研究结果并不一致。因此，我们旨在通过荟萃分析研究孕期 PFAS 暴露与后代 ADHD 和 ASD 之间的关系。全面检索了 PubMed、EMBASE 和 Web of Science 等在线数据库，以获取截至 2021 年 7 月之前开展的合格研究。本分析纳入了 11 项研究（共 8493 名参与者）。汇总结果表明，在最高四分位组中，接触全氟辛烷磺酸（PFOS）与 ADHD 呈负相关，接触全氟辛酸（PFOA）与 ADHD 呈正相关。全氟壬酸（PFNA）与 ASD 之间也存在负相关。总 PFAS 浓度组与神经行为问题之间无关联。试验序贯分析显示结果不稳定。我们的研究结果表明，孕期接触 PFOA 和 PFOS 可能与后代的 ADHD 有关，而孕期接触 PFOS 和 PFNA 可能与后代的 ASD 有关。鉴于大多数关联的证据有限，需要开展更多的研究来验证这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/76a50c445ac5/ijerph-20-01668-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/1d325188ebee/ijerph-20-01668-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/f13f100c5958/ijerph-20-01668-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/716197596ee6/ijerph-20-01668-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/5c933f9601e1/ijerph-20-01668-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/48f6a146462c/ijerph-20-01668-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/cf1a09f87e2f/ijerph-20-01668-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/76a50c445ac5/ijerph-20-01668-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/1d325188ebee/ijerph-20-01668-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/f13f100c5958/ijerph-20-01668-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/716197596ee6/ijerph-20-01668-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/5c933f9601e1/ijerph-20-01668-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/48f6a146462c/ijerph-20-01668-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/cf1a09f87e2f/ijerph-20-01668-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8465/9914055/76a50c445ac5/ijerph-20-01668-g007.jpg

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