吗啡诱导的镇痛作用与暴露于低强度60赫兹磁场：小鼠夜间镇痛作用的抑制是磁场强度的函数。
Morphine-induced analgesia and exposure to low-intensity 60-Hz magnetic fields: inhibition of nocturnal analgesia in mice is a function of magnetic field intensity.
作者信息
Ossenkopp K P, Kavaliers M
机构信息
Department of Psychology, Faculty of Dentistry, University of Western Ontario, London, Canada.
出版信息
Brain Res. 1987 Aug 25;418(2):356-60. doi: 10.1016/0006-8993(87)90103-x.
In 2 experiments male CF-1 mice were exposed for 60 min, during the mid-dark period of the day-night cycle, to low-intensity (0.5-1.5 gauss, rms) 60-Hz magnetic fields and then tested for levels of analgesia induced by morphine (10 mg/kg) injections. The magnetic field exposures inhibited the degree of morphine-induced analgesia in a field intensity-dependent manner in both experiments (P less than 0.01) with the largest inhibitory effect after exposure to the 1.5-gauss field. Analysis of the combined data from the two experiments revealed a significant (P less than 0.001) linear relationship between level of analgesia and magnetic field intensity. Thus, these data demonstrated a functional relationship between the behavioral effects of morphine in mice and the strength of the 60-Hz magnetic field. Possible mechanisms underlying these effects are discussed.
在2项实验中，雄性CF-1小鼠在昼夜循环的黑暗期中期暴露于低强度（均方根值为0.5 - 1.5高斯）的60赫兹磁场中60分钟，然后检测吗啡（10毫克/千克）注射诱导的镇痛水平。在两项实验中，磁场暴露均以场强依赖的方式抑制了吗啡诱导的镇痛程度（P < 0.01），暴露于1.5高斯场后抑制作用最大。对两项实验的合并数据进行分析发现，镇痛水平与磁场强度之间存在显著的（P < 0.001）线性关系。因此，这些数据证明了小鼠体内吗啡的行为效应与60赫兹磁场强度之间存在功能关系。文中讨论了这些效应潜在的可能机制。
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