Baskys A, Niesen C E, Carlen P L
Playfair Neuroscience Unit, Toronto Western Hospital, Ont., Canada.
Brain Res. 1987 Sep 1;419(1-2):112-8. doi: 10.1016/0006-8993(87)90574-9.
The effects of serotonin (5-HT) on dentate granule (DG) neurons in hippocampal slices taken from young mature (6-8 months) and old (25-29 months) rats were compared. Intracellular measurements of membrane potential, cell input resistance and slow postspike afterhyperpolarization did not differ significantly between young and old neurons. Neurons recorded in slices taken from old animals responded with less hyperpolarization to increasing doses of the drug, and their responses were significantly reduced after repeated applications of 5-HT. Serotonin-mediated reduction of the slow afterhyperpolarization in young DG neurons was less prominent or totally absent in the old cells. It is concluded that serotonergic postsynaptic actions are impaired in old age.
比较了血清素（5-羟色胺，5-HT）对取自年轻成熟（6-8个月）和老年（25-29个月）大鼠的海马切片中齿状颗粒（DG）神经元的影响。年轻和老年神经元在膜电位、细胞输入电阻和峰后慢超极化的细胞内测量方面没有显著差异。取自老年动物切片中记录的神经元对增加剂量药物的超极化反应较小，并且在重复应用5-HT后其反应显著降低。血清素介导的年轻DG神经元慢超极化的减少在老年细胞中不那么明显或完全不存在。得出结论，老年时血清素能突触后作用受损。
