Ueda H, Fukushima N, Yoshihara Y, Takagi H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Brain Res. 1987 Sep 1;419(1-2):197-200. doi: 10.1016/0006-8993(87)90583-x.
The neuropeptide kyotorphin (Tyr-Arg) released 45Ca2+ from synaptosomal membrane preparations of the rat lower brainstem. This dipeptide also decreased plasma membrane-bound Ca2+ ([Ca2+]m), determined using chlorotetracycline, in the slice and synaptosome of the rat lower brainstem. Taken together with other data indicating that kyotorphin induces an increase in synaptosomal intracellular Ca2+ ([Ca2+]i) in a Ca2+ channel-independent manner, it is suggested that kyotorphin may mobilize the [Ca2+]m and thus increase the [Ca2+]i in the nerve terminals of the rat lower brainstem.
