James J. Peters VA Medical Center, Bronx, NY 10468, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Int J Environ Res Public Health. 2023 Jan 31;20(3):2502. doi: 10.3390/ijerph20032502.
Bipolar disorder is associated with suicidal behavior. The risk of suicide for individuals with bipolar disorder is up to 20-30 times larger than that of the general population. Considerable evidence suggests that testosterone may play a role in the pathophysiology of suicidal behavior in both men and women with bipolar disorder and other psychiatric conditions. Testosterone has complex effects on psychological traits. It affects mood and behavior, including interactions with other people. Testosterone regulates pro-active and re-active aspects of aggression. Probably, both high and low levels of testosterone may contribute to the neurobiology of suicide in various patient populations. The effects of endogenous and exogenous testosterone on suicidality in patients with bipolar disorder need further investigation. The aim of this commentary article is to provide a commentary on the author's work on the topic, summarize the literature on testosterone, bipolar disorder, and suicide, and encourage future research on this poorly studied topic.
双相情感障碍与自杀行为有关。双相情感障碍患者的自杀风险比普通人群高 20-30 倍。大量证据表明，睾丸激素可能在双相情感障碍和其他精神疾病患者的自杀行为的病理生理学中发挥作用。睾丸激素对心理特征有复杂的影响。它影响情绪和行为，包括与他人的互动。睾丸激素调节积极和消极的攻击性。可能，高和低水平的睾丸激素都可能导致各种患者群体的自杀神经生物学。内源性和外源性睾丸激素对双相情感障碍患者自杀的影响需要进一步研究。本文的目的是对作者关于该主题的工作进行评论，总结关于睾丸激素、双相情感障碍和自杀的文献，并鼓励对这个研究不足的课题进行进一步研究。
