Division of Respiratory Therapy, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi 600, Taiwan.
Department of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi 600, Taiwan.
Int J Environ Res Public Health. 2023 Feb 1;20(3):2656. doi: 10.3390/ijerph20032656.
Pulmonary tuberculosis (TB), a global health problem, is typically caused by the bacterium . Herpes zoster (HZ) is caused by the reactivation of the varicella-zoster virus (VZV). The reactivation of VZV can be caused by stress. We investigated whether pulmonary TB increases the risk of HZ development.
This study used data that sampled a population of 2 million people in 2000 from the National Health Insurance Research Database. This cohort study observed Taiwanese patients aged 20-100 years with pulmonary TB from 2000 to 2017 (tracked to 2018). Pulmonary TB was defined as having two or more outpatient diagnoses or at least one admission record. To address potential bias caused by confounding factors, the control cohort and pulmonary TB cohort were matched 1:1 by age, gender, index year, and comorbidities. Patients with HZ before the index date were excluded.
A total of 30,805 patients were in the pulmonary TB and control cohorts. The incidence rate of HZ in pulmonary TB and control cohorts were 12.00 and 9.66 per 1000 person-years, respectively. The risk of HZ in the pulmonary TB cohort (adjusted hazard ratios = 1.23; 95% confidence interval = 1.16-1.30) was significantly higher than that of in control cohort. Among patients without comorbidities, the patients with TB were 1.28-fold more likely to have HZ than those without TB.
Patients with TB should be well treated to avoid the potential risk of HZ occurrence. Although we identified the association between pulmonary TB and HZ, further studies are needed to confirm the result.
肺结核（TB）是一个全球性的健康问题，通常由细菌引起。带状疱疹（HZ）是由水痘带状疱疹病毒（VZV）的再激活引起的。VZV 的再激活可由压力引起。我们研究了肺结核是否会增加 HZ 发病的风险。
本研究使用了来自 2000 年国民健康保险研究数据库的 200 万人的数据。这项队列研究观察了 2000 年至 2017 年（追踪至 2018 年）期间患有肺结核的 20-100 岁台湾患者。肺结核的定义是有两次或两次以上的门诊诊断或至少有一次住院记录。为了解决混杂因素引起的潜在偏倚，对照组和肺结核组按年龄、性别、指数年和合并症进行 1:1 匹配。排除在指数日期之前患有 HZ 的患者。
共有 30805 名患者进入肺结核和对照组。肺结核和对照组的 HZ 发生率分别为 12.00 和 9.66/1000 人年。肺结核组的 HZ 风险（调整后的危险比=1.23；95%置信区间=1.16-1.30）明显高于对照组。在无合并症的患者中，患有肺结核的患者发生 HZ 的可能性是未患有肺结核的患者的 1.28 倍。
肺结核患者应接受良好的治疗，以避免潜在的 HZ 发病风险。尽管我们确定了肺结核与 HZ 之间的关联，但还需要进一步的研究来证实这一结果。
