Department of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Department of Optometry/Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan.
PLoS One. 2021 Nov 24;16(11):e0259942. doi: 10.1371/journal.pone.0259942. eCollection 2021.
Infection, chronic pain and depression are considered risk factors for herpes zoster (HZ). However, the correlation between plantar fascial fibromatosis (PFF) and HZ remains unknown. This study investigated HZ risk in patients with PFF.
Data was extracted from the Longitudinal Health Insurance Database 2000, which is a subsample of the Taiwan National Health Insurance (NHI) Research Database and contains 1 million NHI beneficiaries. Between 2000 and 2012, patients diagnosed as having PFF were included in the case cohort. Every case was age and sex-matched with individuals without PFF through 1:4 frequency matching (control cohort). The end of the follow-up was defined as December 31, 2013, the date of HZ diagnosis, death, emigration, or withdrawal from the NHI program.
In total, 4,729 patients were diagnosed as having PFF and were matched with 18,916 individuals without PFF. Patients with PFF were 1.23 times more likely to develop HZ than were those without PFF. Among those aged ≥65 years, patients with PFF had a higher HZ risk than did those without PFF (adjusted hazard ratio [aHR] = 1.48). Men with PFF had a significantly higher risk of HZ than did men without PFF (aHR = 1.44).
Patients with PFF, particularly older and male patients, having a high HZ risk and may thus be vaccinated for HZ.
感染、慢性疼痛和抑郁被认为是带状疱疹（HZ）的危险因素。然而，足底筋膜炎（PFF）与 HZ 之间的相关性尚不清楚。本研究调查了 PFF 患者的 HZ 风险。
数据取自 2000 年纵向健康保险数据库（LIS），该数据库是台湾全民健康保险（NHI）研究数据库的一个子样本，包含 100 万 NHI 受益人的数据。2000 年至 2012 年间，患有 PFF 的患者被纳入病例队列。通过 1:4 频率匹配（对照组），每位病例与无 PFF 的个体按年龄和性别匹配。随访结束时间定义为 2013 年 12 月 31 日，即 HZ 诊断、死亡、移民或退出 NHI 计划的日期。
共有 4729 例患者被诊断为患有 PFF，并与 18916 例无 PFF 的个体匹配。与无 PFF 的个体相比，患有 PFF 的个体发生 HZ 的可能性高 1.23 倍。在年龄≥65 岁的患者中，患有 PFF 的患者发生 HZ 的风险高于无 PFF 的患者（调整后的危险比[aHR]=1.48）。患有 PFF 的男性发生 HZ 的风险明显高于无 PFF 的男性（aHR=1.44）。
患有 PFF 的患者，尤其是老年和男性患者，发生 HZ 的风险较高，因此可能需要接种 HZ 疫苗。
