Orzi F, Passarelli F, Diana G, Fieschi C
Dipartimento Scienze Neurologiche, Università di Roma, Italy.
Brain Res. 1987 Oct 13;423(1-2):144-8. doi: 10.1016/0006-8993(87)90834-1.
Local rates of cerebral glucose utilization (LCGU) were determined in adult rats submitted to electroconvulsive shock (ECS) treatment. One group of rats (n = 5) received a single ECS, a second group (n = 5) was treated once daily for 7 days. A third group (n = 5) of unshocked rats served as control. LCGU measurements were performed one day after either the single or the last ECS. Following a single ECS, most of the 45 brain regions examined exhibited lower rates of LCGU than controls, in contrast after repeated ECS treatment the metabolic activity results increased in segments of the hippocampus. The results indicate that repeated ECS treatment selectively increases metabolic rates within the hippocampus, a structure of the limbic system thought to be related to affective disorders and memory.
对接受电休克（ECS）治疗的成年大鼠测定了局部脑葡萄糖利用率（LCGU）。一组大鼠（n = 5）接受单次ECS，第二组（n = 5）每天治疗一次，共7天。第三组（n = 5）未受电击的大鼠作为对照。在单次或最后一次ECS后的一天进行LCGU测量。单次ECS后，所检查的45个脑区中的大多数显示出比对照更低的LCGU率，相反，重复ECS治疗后，海马体部分的代谢活性结果增加。结果表明，重复ECS治疗选择性地提高了海马体中的代谢率，海马体是边缘系统的一个结构，被认为与情感障碍和记忆有关。
