Dam M, London E D
Brain Res. 1984 Mar 12;295(1):137-44. doi: 10.1016/0006-8993(84)90824-2.
The [14C]2-deoxy-D-glucose technique was used to test the effects of central muscarinic stimulation or antagonism on local cerebral glucose utilization (LCGU) in the rat limbic system. Systemic administration of the muscarinic agonist oxotremorine (OXO, 0.05, 0.1 or 0.7 mg/kg, i.p.), increased LCGU in the pre- and postsubiculum, anterior nuclei of the thalamus, mammillary bodies, retrosplenial medial cortex, medial septum, postcommissural fornix and mammillothalamic tract. Scopolamine (2.5 mg/kg, i.p.) blocked these effects, and independently decreased LCGU in the pre- and postsubiculum, anterior thalamic nuclei, and retrosplenial medial cortex. The affected brain regions are components of, or are connected with, the Papez circuit.
采用[14C]2-脱氧-D-葡萄糖技术，来测试中枢毒蕈碱刺激或拮抗对大鼠边缘系统局部脑葡萄糖利用（LCGU）的影响。毒蕈碱激动剂氧化震颤素（OXO，0.05、0.1或0.7毫克/千克，腹腔注射）的全身给药，增加了海马下前、后区、丘脑前核、乳头体、压后内侧皮质、内侧隔、穹窿后连合和乳头丘脑束的LCGU。东莨菪碱（2.5毫克/千克，腹腔注射）阻断了这些作用，并独立降低了海马下前、后区、丘脑前核和压后内侧皮质的LCGU。受影响的脑区是帕佩兹环路的组成部分或与之相连。
