葡萄糖-6-磷酸脱氢酶缺乏症是否是自身免疫性甲状腺疾病的危险因素？一项回顾性病例对照研究。
Is Glucose-6-Phosphate Dehydrogenase Deficiency a Risk Factor for Autoimmune Thyroid Disease? A Retrospective Case-Control Study.
机构信息
Dipartimento di Medicina, Chirurgia e Farmacia, Clinica Medica, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.
Baylor College of Medicine, One Baylor Plaza Blvd, Houston, TX 77030, USA.
出版信息
Int J Environ Res Public Health. 2023 Feb 3;20(3):2709. doi: 10.3390/ijerph20032709.
BACKGROUND
The risk of developing thyroid disorders (TDs) in subjects with inherited glucose-6-phosphate dehydrogenase (G6PD) deficiency is unknown. The aim of this study was to explore the association between autoimmune (AITD) and G6PD deficiency in Northern Sardinia, in a population with a high frequency of these two conditions.
METHODS
In this retrospective single-center case-control study, demographic and clinical data were collected from patients examined in a tertiary referral Gastroenterology Section of a teaching hospital.
RESULTS
In 8894 subjects examined (64.7% females), 1218 patients were diagnosed with TDs; more specifically, 767 were diagnosed with AITD and 451 were not (non-AITD). Overall, G6PD deficiency was more prevalent in TD patients compared with patients without TD (controls) (16.7% vs. 11.2%; < 0.0001). Multivariable logistic regression analysis (after adjusting for age, sex, excess weight and smoking habits), confirmed a higher risk of AITD among G6PD deficient patients with an odds ratio (OR) of 1.36 and 95% confidence interval (CI) of 1.11-1.6, female patients (OR 1.33, 95% CI 1.07-1.65) and overweight patients (OR 1.22, 95% CI 1.03-1.44).
CONCLUSIONS
The risk of AITD is increased in carriers of G6PD deficiency. A careful assessment of thyroid function is advisable in patients with inherited G6PD defects.
背景
患有遗传性葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症的患者发生甲状腺疾病（TDs）的风险尚不清楚。本研究旨在探索北撒丁岛人群中自身免疫性甲状腺疾病（AITD）与 G6PD 缺乏症之间的关联，该人群中这两种疾病的发病率都很高。
方法
在这项回顾性单中心病例对照研究中，我们从一家教学医院的三级转诊胃肠病学科检查的患者中收集了人口统计学和临床数据。
结果
在 8894 名受检者（64.7%为女性）中，有 1218 名患者被诊断为 TDs；更具体地说，767 名被诊断为 AITD，451 名未被诊断为 AITD（非 AITD）。总的来说，与没有 TD（对照组）的患者相比，TD 患者中 G6PD 缺乏症更为常见（16.7%比 11.2%；<0.0001）。多变量逻辑回归分析（调整年龄、性别、超重和吸烟习惯后）证实，G6PD 缺乏症患者发生 AITD 的风险更高，优势比（OR）为 1.36，95%置信区间（CI）为 1.11-1.6，女性患者（OR 1.33，95% CI 1.07-1.65）和超重患者（OR 1.22，95% CI 1.03-1.44）。
结论
G6PD 缺乏症携带者发生 AITD 的风险增加。对于遗传性 G6PD 缺陷患者，建议仔细评估甲状腺功能。
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