Department of Ophthalmology and Visual Science, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul 03312, Republic of Korea.
Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul 14662, Republic of Korea.
Int J Mol Sci. 2023 Jan 20;24(3):2036. doi: 10.3390/ijms24032036.
Central obesity is one of the major risk factors for type 2 diabetes mellitus (DM), and the most common complication of DM is diabetic retinopathy. However, the exact relationship between obesity and DR remains unknown. In this study, we evaluate the effect of obesity on DR by comparing the aqueous humor-derived adipokines. For the analysis, 37 DR patients and 29 non-DR-patients participated. To evaluate the obesity of the patients, body mass index (BMI) and waist circumference (WC) were used. By comparing the concentrations of adipokines obtained from the aqueous humor of the two groups, the relationship between DR and adipokines was analyzed. In addition, by analyzing the correlation between obesity and adipokines in patients, the relationship between central obesity and DR was finally confirmed. The WC was significantly higher in patients than in the non-patient group. The concentrations of all adipokines compared in this study were significantly higher in the DR group than in the non-DM group ( < 0.05). Among them, adiponectin, leptin, TNF-α, Factor D (adipsin), lipocalin-2 (NGAL), Serpin E1 (PAI-1), and CXCL8 (IL-8) were confirmed to have a positive correlation with central obesity (defined as WC). These findings suggest that central obesity is strongly associated with the risk of DR.
中心性肥胖是 2 型糖尿病（DM）的主要危险因素之一，DM 最常见的并发症是糖尿病性视网膜病变（DR）。然而，肥胖与 DR 的确切关系尚不清楚。在这项研究中，我们通过比较房水中的脂肪因子来评估肥胖对 DR 的影响。为了进行分析，共有 37 名 DR 患者和 29 名非 DR 患者参与。为了评估患者的肥胖程度，使用了体重指数（BMI）和腰围（WC）。通过比较两组房水中脂肪因子的浓度，分析了 DR 与脂肪因子之间的关系。此外，通过分析患者肥胖与脂肪因子之间的相关性，最终证实了中心性肥胖与 DR 之间的关系。与非患者组相比，患者的 WC 明显更高。与非 DM 组相比，本研究比较的所有脂肪因子的浓度在 DR 组均明显升高（<0.05）。其中，脂联素、瘦素、TNF-α、因子 D（adipsin）、脂联素-2（NGAL）、Serpin E1（PAI-1）和 CXCL8（IL-8）与中心性肥胖（定义为 WC）呈正相关。这些发现表明中心性肥胖与 DR 的发病风险密切相关。
