Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Department of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Int J Mol Sci. 2023 Jan 20;24(3):2085. doi: 10.3390/ijms24032085.
Mesenchymal stem cells (MSCs), as a kind of pluripotent stem cells, have attracted much attention in orthopedic diseases, geriatric diseases, metabolic diseases, and sports functions due to their osteogenic potential, chondrogenic differentiation ability, and adipocyte differentiation. Anti-inflammation, anti-fibrosis, angiogenesis promotion, neurogenesis, immune regulation, and secreted growth factors, proteases, hormones, cytokines, and chemokines of MSCs have been widely studied in liver and kidney diseases, cardiovascular and cerebrovascular diseases. In recent years, many studies have shown that the extracellular vesicles of MSCs have similar functions to MSCs transplantation in all the above aspects. Here we review the research progress of MSCs and their exocrine vesicles in recent years.
间充质干细胞（MSCs）作为一种多能干细胞，因其成骨潜能、软骨分化能力和脂肪细胞分化能力，在骨科疾病、老年病、代谢性疾病和运动功能等方面受到广泛关注。MSCs 的抗炎、抗纤维化、促进血管生成、神经生成、免疫调节以及分泌生长因子、蛋白酶、激素、细胞因子和趋化因子在肝脏和肾脏疾病、心血管和脑血管疾病中得到了广泛研究。近年来，许多研究表明 MSCs 的细胞外囊泡在上述所有方面都具有与 MSCs 移植相似的功能。在这里，我们综述了近年来 MSCs 及其外泌体的研究进展。
