Laboratory of Synaptogenesis, Łukasiewicz Research Network-PORT Polish Center for Technology Development, Stabłowicka 147, 54-066 Wrocław, Poland.
Department of Molecular Physiology and Neurobiology, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, Poland.
Int J Mol Sci. 2023 Jan 20;24(3):2103. doi: 10.3390/ijms24032103.
The complexity of the cellular proteome facilitates the control of a wide range of cellular processes. Non-coding RNAs, including microRNAs and long non-coding RNAs, greatly contribute to the repertoire of tools used by cells to orchestrate various functions. Circular RNAs (circRNAs) constitute a specific class of non-coding RNAs that have recently emerged as a widely generated class of molecules produced from many eukaryotic genes that play essential roles in regulating cellular processes in health and disease. This review summarizes current knowledge about circRNAs and focuses on the functions of AMOTL1 circRNAs and AMOTL1 protein. Both products from the AMOTL1 gene have well-known functions in physiology, cancer, and other disorders. Using AMOTL1 as an example, we illustrate how focusing on both circRNAs and proteins produced from the same gene contributes to a better understanding of gene functions.
细胞蛋白质组的复杂性促进了广泛的细胞过程的控制。非编码 RNA，包括 microRNAs 和长非编码 RNA，极大地促进了细胞用于协调各种功能的工具组合。环状 RNA（circRNA）构成一类特殊的非编码 RNA，它们最近作为一类广泛产生的分子出现，这些分子来自许多真核基因，在调节健康和疾病中的细胞过程中发挥着重要作用。这篇综述总结了目前关于 circRNA 的知识，并重点介绍了 AMOTL1 circRNA 和 AMOTL1 蛋白的功能。AMOTL1 基因的这两种产物在生理学、癌症和其他疾病中都具有众所周知的功能。我们以 AMOTL1 为例，说明了关注来自同一基因的 circRNA 和蛋白质如何有助于更好地理解基因功能。
