Laboratório de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), São Paulo 05403-010, Brazil.
Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
Int J Mol Sci. 2023 Jan 26;24(3):2431. doi: 10.3390/ijms24032431.
Leiomyomas (LMs) are the most frequent uterine benign tumors, representing the leading cause of hysterectomy indications worldwide. They are highly associated with women's reproductive complications, and endocrine disruptors may influence their etiology. In this sense, air pollution represents a relevant hormonal disruptor that acts on key signaling pathways, resulting in tumor development and infertility. Our goal was to evaluate submucosal LM samples from patients living in the metropolitan and Sao Paulo city regions, focusing on genes involved in tumor development and infertility features. Twenty-four patients were selected based on their region of residence and clinical information availability. Several genes were differentially expressed between women living in metropolitan areas and Sao Paulo city. Significant associations were observed between , , , and downregulation and contraceptive use in the samples from women living in Sao Paulo city. and downregulation was associated with ethnicity. and were associated with LM treatment and related pathologies, respectively. In the samples from women living in other cities of the metropolitan region, abortion occurrence was associated with upregulation. Although further studies may be necessary, our results showed that air pollution exposure influences the expression of genes related to LM development and female reproductive features.
平滑肌瘤（LMs）是最常见的子宫良性肿瘤，也是全世界导致子宫切除术的主要原因。它们与女性生殖并发症高度相关，环境内分泌干扰物可能影响其病因。在这方面，空气污染是一种重要的激素干扰物，它作用于关键的信号通路，导致肿瘤的发展和不孕。我们的目标是评估居住在大都市区和圣保罗市地区的患者的黏膜下 LM 样本，重点研究与肿瘤发展和不孕特征相关的基因。根据居住地区和临床信息的可用性，选择了 24 名患者。居住在圣保罗市的女性样本中，有几个基因在大都会地区和圣保罗市的女性之间存在差异表达。在居住在圣保罗市的女性样本中，观察到 、 、 、 和 下调与避孕药具的使用之间存在显著关联。下调与种族有关。下调与 LM 治疗和相关病理有关。在居住在大都市区其他城市的女性样本中，流产的发生与上调有关。尽管还需要进一步的研究，但我们的结果表明，空气污染暴露会影响与 LM 发展和女性生殖特征相关的基因的表达。
